{"id":"W7117548335","doi":"10.1016/j.bbi.2025.106245","title":"Epigenetic biomarkers of inflammation in studies on mental health: Current applications, limitations, and future directions","year":2025,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Northern British Columbia","funders":"European Research Council; European Commission","keywords":"Epigenetics; Inflammation; Mental health; Biomarker; Epigenesis; Relation (database)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757422,0.00008627411,0.0001242141,0.0002268198,0.0002704735,0.00001513582,0.00006333306,0.00002904222,0.000001891337],"category_scores_gemma":[0.0001510282,0.00008343684,0.00002082015,0.0003951239,0.000165421,0.00006495095,0.00004582822,0.0001111956,6.721617e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003656248,"about_ca_system_score_gemma":0.00003736651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002935665,"about_ca_topic_score_gemma":0.0001139298,"domain_scores_codex":[0.9992276,0.0001952948,0.000241354,0.0001658948,0.0000733386,0.00009655981],"domain_scores_gemma":[0.9994697,0.0002680995,0.00007808579,0.0001374961,0.00001939516,0.00002722093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00003298301,0.0003501422,0.005294556,0.0001188143,0.000006716242,1.468154e-7,0.002918856,9.127547e-7,0.04971708,0.00379977,0.0003129573,0.9374471],"study_design_scores_gemma":[0.001037142,0.0001403884,0.9269759,0.000137317,0.00001223287,0.000002110728,0.007081124,0.00002385675,0.02951574,0.0007909638,0.03412506,0.0001581768],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864381,0.00860807,0.00001101733,0.003909521,0.0001887006,0.0006666759,0.00002851374,0.00002275519,0.0001266318],"genre_scores_gemma":[0.9821616,0.01731829,0.00005842058,0.0001817351,0.0000130496,0.0002116465,0.00001539917,0.000004589629,0.00003527256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9372889,"threshold_uncertainty_score":0.3402456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05379538915512366,"score_gpt":0.3511861692366208,"score_spread":0.2973907800814972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}