{"id":"W7117558201","doi":"10.1021/acsptsci.5c00726","title":"Deciphering Opioid Peptide Binding Modes at Atypical Chemokine Receptor 3","year":2025,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Fonds National de la Recherche Luxembourg; Deutsche Forschungsgemeinschaft; European Cooperation in Science and Technology; Joachim Herz Stiftung","keywords":"Dynorphin; Nociceptin receptor; Pharmacophore; Ligand (biochemistry); Opioid receptor; Internalization; G protein-coupled receptor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001674434,0.0006612808,0.0004767769,0.0001933602,0.0004581633,0.0003738207,0.0008405501,0.0007808748,0.009041736],"category_scores_gemma":[0.0002082404,0.0002355296,0.0005522802,0.0001885087,0.0002426931,0.000543073,0.0003373244,0.0008505762,0.0008851999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006463099,"about_ca_system_score_gemma":0.0007632726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005816142,"about_ca_topic_score_gemma":0.004345257,"domain_scores_codex":[0.9998882,0.00001080666,0.000003483212,0.0000191633,0.00004413831,0.00003425976],"domain_scores_gemma":[0.9999375,0.00002384373,0.000007988584,0.000005458111,0.00001488731,0.00001032402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008288151,0.0003713925,0.007429253,0.0008341764,0.0002742093,0.001384347,0.0002706779,0.4753684,0.4754441,0.01006441,0.009060998,0.01866925],"study_design_scores_gemma":[0.00007197489,0.0001892535,0.001905529,0.00002184187,0.00004435492,0.000114741,0.00008805665,0.9479971,0.04494514,0.00149682,0.003080895,0.00004439889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9351562,0.001159923,0.04169508,0.0008433811,0.00008991369,0.00009082897,0.004152239,0.001525227,0.01528715],"genre_scores_gemma":[0.9700161,0.001016916,0.02300103,0.0001730838,0.00001469567,0.0001220879,0.002886014,0.0002446694,0.002525319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009041736,"threshold_uncertainty_score":0.03024757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113572206533058,"score_gpt":0.2973773950853763,"score_spread":0.2862416730200457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}