{"id":"W7117571896","doi":"10.1186/s10020-025-01414-z","title":"CSF metabolomic signature during therapy for childhood acute lymphoblastic leukemia predicts subsequent working memory impairment","year":2025,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Cancer-related cognitive impairment studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute","keywords":"Metabolome; Cerebrospinal fluid; Metabolomics; Working memory; Chemotherapy; Biomarker; Neurotoxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002374439,0.0002698046,0.0003130877,0.0004269819,0.0001739134,0.0004434505,0.0001496949,0.0002179902,0.0006281934],"category_scores_gemma":[0.000883133,0.00007313897,0.0001494474,0.0005408481,0.0001309701,0.0001556166,0.0002764179,0.000308767,0.0001111432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004106493,"about_ca_system_score_gemma":0.000306808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001442302,"about_ca_topic_score_gemma":0.00215946,"domain_scores_codex":[0.9998765,0.00002963113,0.0000116466,0.00002771577,0.00003085261,0.00002354285],"domain_scores_gemma":[0.9995702,0.00007182803,0.0002325868,0.00002448517,0.00004541687,0.00005555084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002697951,0.0001476261,0.9493031,0.000057824,0.0001297771,0.0002728235,0.000114286,0.0003754501,0.0275342,0.0000401875,0.0004601619,0.01886661],"study_design_scores_gemma":[0.00001466452,0.0004236932,0.9949811,0.00001016261,0.00004704249,0.0004950937,0.0000882145,0.0003663162,0.003033751,0.0000508331,0.000484326,0.000004707078],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986744,0.0004155268,0.000126369,0.00004196733,0.000004005553,0.00001134163,0.0004632167,0.000009237191,0.0002539932],"genre_scores_gemma":[0.9985435,0.0002322376,0.0002117508,0.00004503333,0.00000748113,0.00002038279,0.000829604,0.00000397949,0.0001060467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442302,"threshold_uncertainty_score":0.002979457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007459822003915701,"score_gpt":0.2593020160168932,"score_spread":0.2518421940129775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}