{"id":"W7117579014","doi":"10.30683/1927-7229.2025.14.15","title":"Precision Reprogramming of Lung Cancer Biomarkers via CRISPR/Cas9: A Paradigm Shift in Personalized Immunotherapy","year":2025,"lang":"","type":"article","venue":"Journal of Analytical Oncology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Immunotherapy; Biomarker; Reprogramming; CRISPR; Epigenetics; Immune system; Immune checkpoint; Precision medicine; Cancer immunotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001481229,0.0003443413,0.001185709,0.0005568166,0.00005340247,0.00002885752,0.0004656625,0.0006697775,0.0001620227],"category_scores_gemma":[0.0003220338,0.0003185352,0.0007108519,0.0006742048,0.0003567423,0.00001282259,0.000136381,0.0005712776,6.245438e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003522185,"about_ca_system_score_gemma":0.001163889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000106461,"about_ca_topic_score_gemma":0.0001121319,"domain_scores_codex":[0.9965152,0.0003122568,0.001868014,0.0004483156,0.0003114815,0.0005446972],"domain_scores_gemma":[0.9982245,0.0002636775,0.000706776,0.0003895455,0.0002222307,0.0001932662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02609201,0.004397024,0.1118499,0.001408251,0.01256171,0.0007516056,0.002379318,0.01203865,0.298291,0.002315808,0.005108732,0.522806],"study_design_scores_gemma":[0.04579474,0.01712213,0.1013746,0.005010119,0.004659553,0.0008551702,0.001772551,0.1254708,0.1012453,0.004913671,0.5890697,0.002711582],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5685695,0.1243814,0.2943574,0.008829762,0.002019756,0.0006346806,0.00001703784,0.000005917765,0.001184605],"genre_scores_gemma":[0.9858888,0.01190949,0.001509123,0.0002310225,0.0002463764,0.000009385917,0.000003906081,0.00002712608,0.0001747988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.583961,"threshold_uncertainty_score":0.9999267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009511809304085822,"score_gpt":0.3849306752463554,"score_spread":0.3754188659422696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}