{"id":"W7117579289","doi":"10.1186/s13073-025-01574-x","title":"Single-cell RNA-seq analysis of longitudinal CD4+ T cell samples reveals cell-type-specific changes during early stages of type 1 diabetes","year":2025,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; European Research Council; Biocenter Finland; Canadian Institutes of Health Research; Jane ja Aatos Erkon Säätiö; China Scholarship Council; National Institutes of Health; Novo Nordisk; Academy of Finland; Novo Nordisk Fonden; Turun Yliopisto; European Foundation for the Study of Diabetes; Eunice Kennedy Shriver National Institute of Child Health and Human Development; European Commission","keywords":"Type 1 diabetes; Immune system; Human genetics; Diabetes mellitus; Gene; Transcription factor; Transcription (linguistics); T cell; Autoimmunity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004097086,0.0002330047,0.0005102591,0.0004158124,0.0003922263,0.0007604126,0.0002027964,0.0003305921,0.001633227],"category_scores_gemma":[0.0004499989,0.0001472358,0.0004689571,0.0005306622,0.0002277882,0.0001694148,0.0003084827,0.0006786343,0.0005878796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002155627,"about_ca_system_score_gemma":0.0002834087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001031989,"about_ca_topic_score_gemma":0.002612855,"domain_scores_codex":[0.9996978,0.00002746412,0.00001662951,0.0001298109,0.00006899443,0.0000592751],"domain_scores_gemma":[0.999697,0.00009709771,0.00003918548,0.00002527533,0.00009496403,0.00004646349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001313154,0.0001233311,0.1021493,0.000479275,0.0003370051,0.0002346215,0.000449432,0.002206739,0.8655816,0.000321065,0.003139175,0.02366533],"study_design_scores_gemma":[0.0000888345,0.0006095381,0.8037986,0.0001343507,0.0004394778,0.0007881362,0.0012268,0.01801817,0.1555727,0.00122311,0.018016,0.00008431949],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589616,0.001885641,0.01183743,0.0001460719,0.0001173522,0.00007789225,0.02457842,0.0002312567,0.002164251],"genre_scores_gemma":[0.9420542,0.001012517,0.01775121,0.000633061,0.00008284068,0.0004381712,0.03509748,0.0001795937,0.002750896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633227,"threshold_uncertainty_score":0.00546366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547004652457051,"score_gpt":0.2303581510801562,"score_spread":0.2148881045555857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}