{"id":"W7117583171","doi":"10.64898/2025.12.25.696538","title":"The SARS-CoV-2 nonstructural protein 15 collapses the host cytoskeleton by interacting with the host keratin type II cytoskeletal 1","year":2025,"lang":"","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cytoskeleton; Keratin; Vero cell; Intermediate filament; Virus; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232482,0.0002862012,0.0001504801,0.0001392041,0.0001745407,0.0003257708,0.0001275625,0.000274717,0.0009324001],"category_scores_gemma":[0.00007619034,0.0001179089,0.0003517673,0.00007645563,0.0001806176,0.0002308802,0.0002234771,0.0003474874,0.0003361864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003467551,"about_ca_system_score_gemma":0.0001301976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006267444,"about_ca_topic_score_gemma":0.000716625,"domain_scores_codex":[0.9998461,0.00002613946,0.00001026706,0.0000364938,0.00004702205,0.00003387492],"domain_scores_gemma":[0.9999322,0.000007048371,0.00002614039,0.000007362956,0.000009873436,0.00001736389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001834305,0.000008185351,0.0003478833,0.00001187343,0.000004429246,0.00004065701,0.000005392128,0.00001992721,0.999285,0.00003825628,0.00001169789,0.0002082871],"study_design_scores_gemma":[0.000005375372,0.0001370106,0.01994669,0.000009282284,0.0000108422,0.0004124671,0.00006248563,0.002017346,0.9756643,0.00005945188,0.001671319,0.000003627615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956742,0.0009175689,0.001983216,0.00008357154,0.00002432249,0.00001133854,0.0001029071,0.00002631905,0.001176456],"genre_scores_gemma":[0.9963148,0.0004308056,0.001344686,0.00007305185,0.000005855431,0.000006884582,0.0001775117,0.000005999687,0.00164045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009324001,"threshold_uncertainty_score":0.003119171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00696426951177929,"score_gpt":0.2393770749296882,"score_spread":0.232412805417909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}