{"id":"W7117673105","doi":"10.1016/j.str.2025.12.007","title":"Bacillus subtilis MutL samples multiple conformations during nucleotide binding and hydrolysis","year":2025,"lang":"en","type":"article","venue":"Structure","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología; Canada Research Chairs","keywords":"Nuclease; Bacillus subtilis; Endonuclease; DNA mismatch repair; DNA; Escherichia coli; ATP hydrolysis; Function (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003100359,0.0002835607,0.0003221068,0.0002614577,0.0003056533,0.0006768348,0.0003773338,0.0004030975,0.003247272],"category_scores_gemma":[0.0008289255,0.0003730061,0.0002097993,0.0002679619,0.0003717411,0.000606024,0.0003581685,0.001001781,0.0008185968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005195286,"about_ca_system_score_gemma":0.0002419065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036477,"about_ca_topic_score_gemma":0.001191949,"domain_scores_codex":[0.9997639,0.00003709657,0.000008900579,0.00004719317,0.00006086364,0.00008200759],"domain_scores_gemma":[0.9996647,0.0001030341,0.0001094843,0.00003095399,0.00003600165,0.00005584772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002718162,0.0002386907,0.01188307,0.0001836618,0.0001120134,0.0007980917,0.0005966004,0.002681748,0.9596288,0.00141162,0.001019936,0.01872757],"study_design_scores_gemma":[0.0001552937,0.000968664,0.04223897,0.00005703428,0.0000655172,0.001451734,0.0007021744,0.01355277,0.9323444,0.0009982253,0.007343662,0.0001216008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962152,0.0005492443,0.001300788,0.0001659642,0.00001950929,0.000005183407,0.0001394602,0.00004757253,0.001556984],"genre_scores_gemma":[0.9975179,0.0001781935,0.0005117214,0.00006862787,0.000005868431,0.000006073013,0.0004018908,0.00003366849,0.001276114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003247272,"threshold_uncertainty_score":0.01086318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008744613042492695,"score_gpt":0.2443384313756793,"score_spread":0.2355938183331866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}