{"id":"W7117694170","doi":"10.1038/s41408-025-01444-0","title":"Effect of prior therapy on the clinical activity of imetelstat in patients with transfusion-dependent, ESA-relapsed or -refractory/-ineligible LR-MDS","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Journal","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Hematology; Clinical trial; MEDLINE; Chemotherapy; Text mining","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008070038,0.0002239451,0.000727188,0.0001601629,0.00008763694,0.00001384484,0.0001215746,0.0001008769,0.0003326914],"category_scores_gemma":[0.000141514,0.00009734578,0.0001934844,0.0003003239,0.00008646402,0.00006118524,0.00001473096,0.0005606652,0.000001114329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008891911,"about_ca_system_score_gemma":0.000563289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001891544,"about_ca_topic_score_gemma":0.0002062431,"domain_scores_codex":[0.9980431,0.000464652,0.0005410621,0.0002375056,0.0005007223,0.0002130172],"domain_scores_gemma":[0.997996,0.001144852,0.0003205116,0.0002558027,0.0001876822,0.00009514324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02508797,0.004102929,0.8681308,0.00008063394,0.0009980189,0.0000260184,0.0001717908,0.00001836392,0.0007865455,0.00001044562,0.0001786029,0.1004079],"study_design_scores_gemma":[0.03858728,0.01715505,0.768477,0.001125785,0.0004805663,0.00000636255,0.0000134231,0.000009237654,0.1738695,0.0000115584,0.0001697947,0.00009447685],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970745,0.0005343547,0.00001298651,0.0007347273,0.0002435401,0.001131254,0.00002768275,0.00000617335,0.0002347973],"genre_scores_gemma":[0.9952047,0.004258567,0.00003517422,0.0002191722,0.00007139133,0.00009166877,0.000001845989,0.00001739071,0.0001000171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1730829,"threshold_uncertainty_score":0.3969646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976159103975093,"score_gpt":0.3497240675500856,"score_spread":0.3299624765103346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}