{"id":"W7117694170","doi":"10.1038/s41408-025-01444-0","title":"Effect of prior therapy on the clinical activity of imetelstat in patients with transfusion-dependent, ESA-relapsed or -refractory/-ineligible LR-MDS","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Journal","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Hematology; Clinical trial; MEDLINE; Chemotherapy; Text mining","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004855178,0.0002382474,0.0009138319,0.0002043414,0.0001864688,0.0004538679,0.0002506662,0.0003318444,0.002570635],"category_scores_gemma":[0.001790384,0.00009527535,0.0005309539,0.000195948,0.0001782973,0.0004982786,0.0002328861,0.001400715,0.0003512746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002660342,"about_ca_system_score_gemma":0.0003736036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003591926,"about_ca_topic_score_gemma":0.001294019,"domain_scores_codex":[0.9998218,0.00006036701,0.0000263254,0.00002871955,0.00002958428,0.00003325102],"domain_scores_gemma":[0.9991401,0.0002244093,0.0001517251,0.00004744283,0.00003865629,0.0003975561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.3646142,0.0133452,0.1103266,0.0009743319,0.00211569,0.0008957375,0.0004753383,0.002400485,0.01656081,0.0003678561,0.005917853,0.4820058],"study_design_scores_gemma":[0.02892218,0.2719386,0.6583381,0.0004739132,0.003800242,0.002051252,0.0003271305,0.004023407,0.005268578,0.0007984189,0.02394829,0.0001098631],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825543,0.01247195,0.0001322789,0.0005724506,0.0001990125,0.00008828902,0.0004239138,0.00003218125,0.003525628],"genre_scores_gemma":[0.9962341,0.001693716,0.000156342,0.0003003346,0.0001600859,0.00005819155,0.0005881739,0.000004285977,0.0008046963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002570635,"threshold_uncertainty_score":0.008599639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976159103975093,"score_gpt":0.3497240675500856,"score_spread":0.3299624765103346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}