{"id":"W7117711669","doi":"10.20944/preprints202512.2694.v1","title":"Precision Medicine Treatment of Alzheimer’s Disease: Successful Randomized Controlled Trial","year":2025,"lang":"","type":"preprint","venue":"Preprints.org","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Randomized controlled trial; Precision medicine; Dementia; Clinical trial; Disease; Alternative medicine; Cognition; Drug trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02850351,0.001381532,0.006247813,0.0007856535,0.0007904664,0.002397772,0.001074965,0.005012655,0.004802352],"category_scores_gemma":[0.02816167,0.0006650799,0.005301538,0.001173782,0.002253051,0.002210403,0.0008811904,0.002121309,0.0005581508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001251137,"about_ca_system_score_gemma":0.002363068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005853117,"about_ca_topic_score_gemma":0.001002841,"domain_scores_codex":[0.9802777,0.01433094,0.001896334,0.001689473,0.001369863,0.0004357237],"domain_scores_gemma":[0.9796667,0.0125023,0.004009367,0.001560706,0.001510528,0.0007503832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8514615,0.004288977,0.001843143,0.0159255,0.02088225,0.0001157902,0.0001428462,0.0007902524,0.001486312,0.001426688,0.00484297,0.09679378],"study_design_scores_gemma":[0.9528585,0.02963638,0.002268846,0.001966195,0.007706719,0.0000452044,0.00002424586,0.000571328,0.0003361141,0.001331717,0.003221734,0.0000331214],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4321146,0.4269941,0.03451073,0.02028003,0.01448984,0.05741756,0.004063434,0.0008517255,0.009278069],"genre_scores_gemma":[0.8565263,0.05127314,0.03554521,0.01294606,0.005416239,0.03409393,0.0014054,0.00008895979,0.002704766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02850351,"threshold_uncertainty_score":0.1507428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1175625399466686,"score_gpt":0.4195142567823419,"score_spread":0.3019517168356733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}