{"id":"W7117737019","doi":"10.64898/2025.12.26.25343034","title":"Hemispheric Asymmetry Defines Brain Aging: Five Reproducible NMF Modes Linked to Sex, Lifestyle, Transdiagnostic Genetic Risk, and Molecular Pathways","year":2025,"lang":"","type":"article","venue":"medRxiv","topic":"Hemispheric Asymmetry in Neuroscience","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Human brain; Imaging genetics; Asymmetry; Generalizability theory; Brain asymmetry; Non-negative matrix factorization; Neuroimaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002140814,0.0004880664,0.0002973242,0.0006951463,0.0003928903,0.0005550145,0.0002818376,0.0002813876,0.003070406],"category_scores_gemma":[0.006267713,0.0001661252,0.0005689641,0.0004909133,0.0006261201,0.0003117396,0.0006714109,0.0004359066,0.0003172558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002578176,"about_ca_system_score_gemma":0.0004847968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003248763,"about_ca_topic_score_gemma":0.005413522,"domain_scores_codex":[0.9994128,0.0001930162,0.00003630467,0.0001951548,0.00009307158,0.00006965336],"domain_scores_gemma":[0.9981838,0.0007432823,0.0003165479,0.0004071966,0.0002538491,0.00009542263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001872542,0.0001496695,0.6342359,0.0003376439,0.0008668147,0.000546472,0.001674914,0.01169796,0.1854077,0.006412332,0.004411326,0.1523867],"study_design_scores_gemma":[0.0000386814,0.0001514409,0.937842,0.00004723758,0.0001774029,0.0007273546,0.0003366309,0.03831024,0.01210206,0.008140107,0.002079274,0.00004758792],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9296502,0.0002809938,0.06680912,0.00009993608,0.00002082977,0.00006181404,0.001269422,0.0001778287,0.001629818],"genre_scores_gemma":[0.9856836,0.00004093787,0.01309417,0.00002202358,0.000007743889,0.00005167476,0.0007282145,0.00005289233,0.0003186553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003248763,"threshold_uncertainty_score":0.0113219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410208210588967,"score_gpt":0.2615038416856914,"score_spread":0.2474017595798017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}