{"id":"W7117737490","doi":"10.1002/brb3.71172","title":"The Role of Sphingolipid Metabolism and Neuron Death in Ischemic Stroke: A New Perspective from Bioinformatics","year":2025,"lang":"en","type":"article","venue":"Brain and Behavior","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Sphingolipid; Perspective (graphical); Neuron; Mechanism (biology); Signal transduction; Cell metabolism; Cellular metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003309966,0.00108359,0.002816838,0.003804926,0.0005723172,0.002918946,0.002014321,0.00115068,0.001666555],"category_scores_gemma":[0.007058226,0.0003748723,0.002177085,0.005554074,0.0008819972,0.00209237,0.001791012,0.002151721,0.001269957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001048372,"about_ca_system_score_gemma":0.00178937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002589164,"about_ca_topic_score_gemma":0.00296847,"domain_scores_codex":[0.9982219,0.0005939129,0.0001558055,0.0006022461,0.0003303329,0.00009579519],"domain_scores_gemma":[0.995209,0.003200273,0.0003764594,0.0003713124,0.0005510554,0.0002918714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001411208,0.0003967035,0.08022344,0.01407119,0.004092956,0.001620005,0.0007558647,0.04550127,0.02245564,0.04715312,0.08868055,0.6936381],"study_design_scores_gemma":[0.0001654571,0.0004795374,0.05849833,0.002967459,0.0018042,0.002126089,0.0009215371,0.2447044,0.005596387,0.3786029,0.303874,0.0002597236],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.06529537,0.3480706,0.4632796,0.04468151,0.002190411,0.0002666316,0.06089591,0.007214271,0.008105747],"genre_scores_gemma":[0.3288011,0.2017694,0.3363353,0.00991887,0.004274117,0.0006634365,0.1143664,0.001112491,0.002758828],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003804926,"threshold_uncertainty_score":0.01750499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006282426090464885,"score_gpt":0.2470393653058578,"score_spread":0.2407569392153929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}