{"id":"W7117753358","doi":"10.1097/sla.0000000000007003","title":"Plasma Cell-free DNA Methylomes for Hepatocellular Carcinoma Detection and Monitoring After Liver Resection or Transplantation","year":2025,"lang":"en","type":"article","venue":"Annals of Surgery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre; Toronto General Hospital; University Health Network","funders":"","keywords":"Liver transplantation; Hepatocellular carcinoma; Resection; Transplantation; Carcinoma; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008419245,0.0003620752,0.0004175306,0.0006655669,0.0001712894,0.0003981013,0.000349005,0.0005301142,0.001553634],"category_scores_gemma":[0.001507827,0.0001651109,0.0002811076,0.0003469219,0.0001781192,0.0002323545,0.000294541,0.0004091275,0.0004189402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003537487,"about_ca_system_score_gemma":0.0002877344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008680315,"about_ca_topic_score_gemma":0.001490014,"domain_scores_codex":[0.9996359,0.00009316074,0.00001685128,0.000117148,0.0001089799,0.00002787773],"domain_scores_gemma":[0.9994634,0.0001680638,0.0001693392,0.00004595731,0.0001005311,0.00005274376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004680555,0.0002627021,0.3803707,0.0005863124,0.0004064935,0.0002384514,0.0001312782,0.004566556,0.4405061,0.0002550537,0.002369278,0.1656266],"study_design_scores_gemma":[0.0002245197,0.003008833,0.6008978,0.0001821859,0.0005471147,0.001951224,0.0001932321,0.08932249,0.2945414,0.001318061,0.00772489,0.00008827243],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9570925,0.007441469,0.02785286,0.0005584925,0.0001021186,0.0001671689,0.004338458,0.0006688253,0.001778141],"genre_scores_gemma":[0.983319,0.0008717278,0.01289925,0.0002462431,0.00005017098,0.0001108992,0.001606105,0.00002221804,0.0008743509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553634,"threshold_uncertainty_score":0.005197406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06732765352147144,"score_gpt":0.2882510767032454,"score_spread":0.220923423181774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}