{"id":"W7117760859","doi":"10.64898/2025.12.29.696828","title":"Post-translational modifications within fibrinaloid microclot complexes distinguish Pre-COVID-19 Postural Orthostatic Tachycardia Syndrome (POTS), Long COVID, and Long COVID-POTS and reveal disease-specific molecular pathways","year":2025,"lang":"","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiovascular Syncope and Autonomic Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; Glycemic Index Laboratories","funders":"","keywords":"Glycation; Fibrinogen; Proteomics; Platelet; Immune system; Diabetes mellitus; Disease; Coagulation; Blood proteins","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587318,0.0003466002,0.0001979934,0.000512634,0.0001456163,0.0004526622,0.0001080193,0.0002967881,0.0008663193],"category_scores_gemma":[0.000313429,0.0001091794,0.0002651234,0.0002438317,0.0002299285,0.0002021834,0.0002560047,0.0003208888,0.0001913198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111412,"about_ca_system_score_gemma":0.00008132785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000492717,"about_ca_topic_score_gemma":0.0004465251,"domain_scores_codex":[0.9998777,0.00001415558,0.00001990857,0.00003947694,0.00002190701,0.00002681905],"domain_scores_gemma":[0.9997597,0.00003171512,0.000118635,0.00001408912,0.00003128423,0.00004469338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00115524,0.00003656077,0.08052644,0.0001138301,0.00007155834,0.00124722,0.0001412856,0.00007898309,0.9110236,0.00009882024,0.0001319223,0.005374454],"study_design_scores_gemma":[0.00004386236,0.0007322821,0.8184026,0.00004949128,0.0001047727,0.01066515,0.0003640143,0.00162625,0.1660231,0.0003723042,0.001598775,0.00001744182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977781,0.0008444077,0.0006865712,0.000036049,0.00000896896,0.00001110064,0.0002970466,0.000009928425,0.0003277874],"genre_scores_gemma":[0.9979346,0.0003042827,0.0008666716,0.00004389134,0.00001485443,0.00001078868,0.0006111958,0.000005184377,0.000208522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008663193,"threshold_uncertainty_score":0.002898157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471184534249854,"score_gpt":0.2389358440795586,"score_spread":0.2242239987370601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}