{"id":"W7118007937","doi":"10.20944/preprints202512.2811.v1","title":"Roles of Mutation, Ploidy, and Recombination in Adaptive Evolution in Divergent Model Yeasts <em>Saccharomyces cerevisiae</em> and the Human Pathogenic <em>Cryptococcus</em>","year":2025,"lang":"","type":"preprint","venue":"Preprints.org","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Adaptation (eye); Adaptive evolution; Population; Variation (astronomy); Genetic variation; Genomics; Population genomics; Mutation; Adaptive response; Evolutionary dynamics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00117166,0.0002578276,0.0005048332,0.0006043387,0.0002611049,0.001379937,0.0004165396,0.0006664095,0.0003704159],"category_scores_gemma":[0.00101409,0.0001449483,0.0004616243,0.0004780707,0.0009085273,0.0007759347,0.0006014609,0.0007668662,0.0001593285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008152576,"about_ca_system_score_gemma":0.0003575745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000743158,"about_ca_topic_score_gemma":0.0005596808,"domain_scores_codex":[0.9996409,0.0001241266,0.0000325524,0.0001097882,0.00006034101,0.00003235143],"domain_scores_gemma":[0.9994961,0.0002596902,0.0001364152,0.00003438285,0.00002862124,0.00004473417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009079341,0.00007656006,0.03281485,0.002792526,0.0003260109,0.002336773,0.001738571,0.04052525,0.6122364,0.1196504,0.001378611,0.1852161],"study_design_scores_gemma":[0.0001562815,0.001127368,0.130378,0.0009893115,0.0008475836,0.008484171,0.003224052,0.09101837,0.3218669,0.3059209,0.1353659,0.0006211021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7872431,0.122815,0.07710411,0.001945464,0.0001196345,0.00003457435,0.0006392408,0.0003321867,0.009766626],"genre_scores_gemma":[0.9626936,0.02523449,0.01053773,0.0001695393,0.00002872023,0.0000240784,0.0003464069,0.00005418049,0.0009112004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001379937,"threshold_uncertainty_score":0.006196439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03735388156580245,"score_gpt":0.3020239804793299,"score_spread":0.2646700989135275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}