{"id":"W7118067715","doi":"10.61373/gp025k.0071","title":"Mirko Manchia: Exploring the biological landscape of psychiatric disorders to innovate clinical management with precision medicine approaches","year":2025,"lang":"","type":"article","venue":"Genomic psychiatry :","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Neuropsychopharmacology; Context (archaeology); Precision medicine; Bipolar disorder; Drug response; Psychiatric genetics; Multidisciplinary approach; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001540076,0.0007729064,0.001317296,0.0007596221,0.0003963201,0.00003048584,0.0008706643,0.0002750683,0.0001816702],"category_scores_gemma":[0.00004006824,0.0004327852,0.0003810002,0.002549064,0.000523389,0.00007138024,0.0004907419,0.000798245,0.00008731973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009279463,"about_ca_system_score_gemma":0.0003006691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006399408,"about_ca_topic_score_gemma":0.000346863,"domain_scores_codex":[0.9948404,0.0003669339,0.002002896,0.001413969,0.0005147918,0.0008609568],"domain_scores_gemma":[0.997202,0.0002482659,0.0004633412,0.001720244,0.00008283025,0.0002832558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003374332,0.002316681,0.7625291,0.000637265,0.002444685,0.000002538954,0.0006233674,0.00008299959,0.00001034463,0.0115987,0.004339576,0.2120405],"study_design_scores_gemma":[0.009179682,0.003816928,0.9428826,0.0009182589,0.002022372,0.00001184282,0.005103062,0.00007430385,0.000004384869,0.004507003,0.03105519,0.0004243825],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8273801,0.06390595,0.004575982,0.05368645,0.009363083,0.004747342,0.00003871658,0.00009220684,0.03621016],"genre_scores_gemma":[0.9760177,0.01287552,0.007664935,0.001212951,0.0008638257,0.0004368073,0.00005239079,0.0000656333,0.0008102842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2116161,"threshold_uncertainty_score":0.9998124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06808320816484827,"score_gpt":0.3074548654548492,"score_spread":0.2393716572900009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}