{"id":"W7118074231","doi":"10.1093/geroni/igaf122.3183","title":"Ketones And Cognition: Insights From A Reverse-Translation Approach In Alzheimer Disease Mice","year":2025,"lang":"en","type":"article","venue":"Innovation in Aging","topic":"Diet and metabolism studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université de Sherbrooke","funders":"","keywords":"Ketogenic diet; Ketone bodies; Dementia; Genetically modified mouse; Transcriptome; Disease; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001866341,0.001339683,0.0009022661,0.001368185,0.0005606023,0.001643522,0.001143771,0.001256378,0.004356544],"category_scores_gemma":[0.0006388044,0.0005645351,0.001209488,0.0004493427,0.0009875082,0.0008010181,0.0008665633,0.003671227,0.001455794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007909035,"about_ca_system_score_gemma":0.0007852632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001125391,"about_ca_topic_score_gemma":0.002030222,"domain_scores_codex":[0.9993753,0.0001540721,0.00006695495,0.0001418656,0.0001559997,0.0001058512],"domain_scores_gemma":[0.9992813,0.0001256134,0.000182603,0.0001068371,0.0001322475,0.0001713892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001325935,0.0006396745,0.0005834835,0.000519919,0.000115452,0.0002487951,0.000141274,0.0004786187,0.9783276,0.004948196,0.001365535,0.01130552],"study_design_scores_gemma":[0.001068877,0.005224354,0.008644968,0.0003860295,0.0007072143,0.001063651,0.0003921983,0.008496456,0.8996022,0.009803626,0.06444633,0.0001640605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7884925,0.02087974,0.1390433,0.01290435,0.002519913,0.0009007416,0.01626487,0.003125381,0.01586916],"genre_scores_gemma":[0.8327544,0.02284824,0.1082615,0.00377152,0.0004434138,0.001772387,0.007112759,0.000868083,0.0221676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004356544,"threshold_uncertainty_score":0.01457405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04168258665678581,"score_gpt":0.3053174923706533,"score_spread":0.2636349057138675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}