{"id":"W7118075936","doi":"10.47743/jpd.2025.32.1.976","title":"PREDICTION OF 3D STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 USING ALPHAFOLD 2 AND SIMULATION OF ITS INTERACTION WITH MITOGEN-ACTIVATED PROTEIN KINASE 6 IN ARABIDOPSIS THALIANA","year":2025,"lang":"","type":"article","venue":"Journal of Plant Development","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Mitogen-activated protein kinase kinase; MAP kinase kinase kinase; MAP2K7; Cyclin-dependent kinase 9; Protein kinase A; c-Raf; Docking (animal); Cyclin-dependent kinase 2; ASK1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001540564,0.0005902835,0.000404115,0.0003120646,0.0005267609,0.0003649641,0.0004979999,0.0005533271,0.002008175],"category_scores_gemma":[0.000220656,0.0003503783,0.0005565677,0.0002777877,0.0001785569,0.0003107474,0.0001675425,0.0003763147,0.0002462739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007938981,"about_ca_system_score_gemma":0.0007704139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008895294,"about_ca_topic_score_gemma":0.008705404,"domain_scores_codex":[0.9999559,0.000009234061,0.000001805218,0.000009529317,0.00001227145,0.00001126624],"domain_scores_gemma":[0.9999193,0.00002678975,0.00001175996,0.000004674454,0.00001640904,0.0000209431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004322239,0.0002159488,0.006585193,0.0001823469,0.00009334852,0.0008599222,0.0001052508,0.9205148,0.06122281,0.002988053,0.001655818,0.00514432],"study_design_scores_gemma":[0.00004915418,0.00007180273,0.001790798,0.000006717468,0.00001089804,0.00004141223,0.00004234637,0.9931039,0.004032084,0.0004238267,0.0004155507,0.00001151596],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987059,0.0001990184,0.008465695,0.0001362764,0.00002308367,0.00002135414,0.0008213368,0.0004489644,0.002825143],"genre_scores_gemma":[0.98764,0.0001959942,0.009971922,0.00002451949,0.000004749857,0.00003861593,0.001381647,0.00007531559,0.0006671959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008895294,"threshold_uncertainty_score":0.01768708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01961443145398404,"score_gpt":0.2446703889125219,"score_spread":0.2250559574585379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}