{"id":"W7118077194","doi":"10.1093/geroni/igaf122.532","title":"Gerotherapeutic compound picolinic acid supports locomotor function and bone health in aged zebrafish","year":2025,"lang":"en","type":"article","venue":"Innovation in Aging","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Picolinic acid; Zebrafish; Regeneration (biology); Metabolite; Body weight; Fish <Actinopterygii>; Staining","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001042361,0.0003537907,0.0003025052,0.0003184173,0.0001415399,0.0001850886,0.0002192482,0.0003202946,0.001473616],"category_scores_gemma":[0.00010172,0.0001085982,0.0002846172,0.0000661908,0.000239755,0.0002374455,0.0002568291,0.0004526706,0.000217493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000287893,"about_ca_system_score_gemma":0.0003871787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001664516,"about_ca_topic_score_gemma":0.004021233,"domain_scores_codex":[0.9999243,0.000009027701,0.000007317718,0.00001754087,0.00001841503,0.00002347246],"domain_scores_gemma":[0.9999403,0.000002588774,0.00001985604,0.000004297812,0.00001295307,0.00001989587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005949757,0.00006589496,0.0003949647,0.0001391825,0.00001224412,0.00005479248,0.0000208546,0.00008575339,0.9954801,0.00004894083,0.00009604574,0.003006334],"study_design_scores_gemma":[0.0001908281,0.007573615,0.02739178,0.00006042115,0.000160439,0.0002302602,0.0002147401,0.001349965,0.9555227,0.0001927791,0.007087728,0.00002471459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993999,0.002450696,0.0013109,0.0001825883,0.0000513122,0.00004808787,0.0005406864,0.0001254407,0.001291341],"genre_scores_gemma":[0.9922432,0.0016378,0.001207495,0.0001113172,0.00001015876,0.00006910398,0.000305454,0.00001881287,0.004396542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001664516,"threshold_uncertainty_score":0.004929721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851134873297177,"score_gpt":0.3358746247943998,"score_spread":0.317363276061428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}