{"id":"W7118253775","doi":"10.1093/ije/dyaf223","title":"Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes","year":2025,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Queen's University Belfast; Queen's University; Wellcome Trust; British Heart Foundation; Department of Health, Northern Ireland","keywords":"Type 2 diabetes; Coronary artery disease; Atherosclerotic cardiovascular disease; Disease; Statin; Workflow; Human genetics; Diabetes mellitus; Coronary heart disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002201273,0.0006550396,0.000474835,0.00108657,0.0004151968,0.0006164608,0.0004694837,0.0007871939,0.003973121],"category_scores_gemma":[0.003891997,0.0002128561,0.001226743,0.0009142351,0.001162679,0.0002267001,0.0004628248,0.0005491072,0.0001327564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002679645,"about_ca_system_score_gemma":0.0006237844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002330923,"about_ca_topic_score_gemma":0.001761072,"domain_scores_codex":[0.9980175,0.0009932087,0.0001309372,0.0005469023,0.0001928983,0.0001185412],"domain_scores_gemma":[0.9960659,0.002697956,0.0006647573,0.0003510156,0.00008962784,0.0001307731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004533132,0.000226009,0.9052826,0.0003168255,0.003120509,0.003667767,0.0005793832,0.001787553,0.03916077,0.01182467,0.0004993226,0.0290014],"study_design_scores_gemma":[0.0005144092,0.0006863523,0.9557095,0.0001379273,0.003000993,0.006597995,0.0004043023,0.00670265,0.005666893,0.01846978,0.002054346,0.00005483907],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817463,0.002449959,0.0111636,0.001576588,0.00003876582,0.00003754701,0.0003748896,0.00009287152,0.002519372],"genre_scores_gemma":[0.9955387,0.0005161021,0.003260869,0.0002869975,0.0000362551,0.00001448535,0.0001233288,0.00001137686,0.0002119423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003973121,"threshold_uncertainty_score":0.01329142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03514509009995791,"score_gpt":0.3302770558806273,"score_spread":0.2951319657806694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}