{"id":"W7118317261","doi":"10.1002/alz70856_105873","title":"Glial fibrillary acidic protein is elevated in preclinical AD","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Glial fibrillary acidic protein; Biomarker; Positron emission tomography; Cognitive decline; Neuropsychology; Neurology; Amyloid (mycology); Amyloid beta","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003555759,0.0003698466,0.0002755653,0.000815211,0.0003297306,0.0005440239,0.0001958748,0.0003796601,0.001285197],"category_scores_gemma":[0.0009413885,0.0001742462,0.0001429631,0.0003762207,0.0002600629,0.0002076707,0.0002417213,0.0003316879,0.0002713157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001695229,"about_ca_system_score_gemma":0.0001673544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001275622,"about_ca_topic_score_gemma":0.001439521,"domain_scores_codex":[0.999868,0.00003226719,0.00001621988,0.00003298176,0.00003209609,0.00001840753],"domain_scores_gemma":[0.9995958,0.00006278846,0.0001646221,0.00001874116,0.00006778143,0.00009014468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002321926,0.000282159,0.9754125,0.0000527005,0.00006985958,0.0006716197,0.0001603841,0.00008528005,0.01511628,0.00005402522,0.0002661663,0.005507139],"study_design_scores_gemma":[0.00001789698,0.0005058298,0.9963593,0.000007141675,0.00003221906,0.001227138,0.0001158651,0.0001715261,0.001231083,0.00008448815,0.0002441009,0.000003502267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988446,0.0002815975,0.00009020486,0.00001670619,0.000005208083,0.00001160357,0.0001071943,0.00001007181,0.000632758],"genre_scores_gemma":[0.9993981,0.00007528772,0.0001603033,0.00001720183,0.000006898661,0.000006280008,0.0001133152,0.000001329915,0.0002211996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285197,"threshold_uncertainty_score":0.004299402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03932290385097911,"score_gpt":0.3647686523437175,"score_spread":0.3254457484927384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}