{"id":"W7118340779","doi":"10.1002/alz70856_105913","title":"Sex differences in tau and synaptic pathologies in a humanized MAPT mouse model revealed by PET imaging","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Tauopathy; Entorhinal cortex; Frontotemporal dementia; Tau protein; Pathological; Hyperphosphorylation; Pet imaging; Hippocampus; Cyclin-dependent kinase 5","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004981608,0.001275731,0.0005212238,0.001974727,0.0004560876,0.0005608725,0.0004374374,0.0009612564,0.004066529],"category_scores_gemma":[0.0002181948,0.0004833176,0.0006798529,0.0004772118,0.0005966426,0.0005076165,0.0003645277,0.001012886,0.000862547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005564001,"about_ca_system_score_gemma":0.0003101838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008632676,"about_ca_topic_score_gemma":0.001395155,"domain_scores_codex":[0.9995912,0.00003824673,0.00004501833,0.0001540791,0.0001062397,0.00006521158],"domain_scores_gemma":[0.9996299,0.00003286309,0.0001629612,0.00004435009,0.00004375492,0.00008614174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001677834,0.0006231903,0.002179526,0.00007675872,0.00003846362,0.001100672,0.0001332647,0.0001119931,0.9896074,0.0003593986,0.0005009435,0.003590696],"study_design_scores_gemma":[0.0006133634,0.007954069,0.07321402,0.0001285418,0.0004122739,0.01485856,0.0005009742,0.003226867,0.88254,0.0009773779,0.01543416,0.0001398018],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851308,0.00107749,0.005728934,0.0003156678,0.0001423073,0.0001827794,0.004914343,0.0003177215,0.002189785],"genre_scores_gemma":[0.9622286,0.001714145,0.008112445,0.0003944519,0.0000583562,0.0009044534,0.005071177,0.0003178642,0.02119851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004066529,"threshold_uncertainty_score":0.01360387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02754099952971459,"score_gpt":0.3034417382687115,"score_spread":0.2759007387389969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}