{"id":"W7118619183","doi":"10.1093/ofid/ofaf809","title":"Controlled Human Infection of Healthy Adults With Lyophilized <i>Neisseria lactamica</i> Induces Asymptomatic, Immunogenic Nasopharyngeal Carriage in the United Kingdom and Mali","year":2025,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Office of Community Development; National Institute for Health and Care Research; Novavax; Government of the United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre; Sanofi; Seqirus; University Hospital Southampton NHS Foundation Trust; GlaxoSmithKline; University College London; AstraZeneca; Afromontane Research Unit, University of the Free State; Pfizer","keywords":"Carriage; Transmission (telecommunications); Meningitis; Nasal administration; Colonization; Bacterial meningitis; Clinical trial; Infection control","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008655298,0.0004553363,0.0004020931,0.0002274999,0.0001855186,0.0003460324,0.0002770839,0.0003411282,0.001593256],"category_scores_gemma":[0.0005860424,0.0003063832,0.0002685036,0.0001857744,0.0004911015,0.0002335599,0.0003409339,0.0004764965,0.0002880685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005180106,"about_ca_system_score_gemma":0.0003665751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00355515,"about_ca_topic_score_gemma":0.005909901,"domain_scores_codex":[0.9990209,0.0005529946,0.00005693106,0.0001402127,0.00009875701,0.000130193],"domain_scores_gemma":[0.9994071,0.000119849,0.0002318834,0.00008855444,0.00007631737,0.00007633222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.02911687,0.006018669,0.01349712,0.0005755638,0.0001335595,0.0002771492,0.0009222629,0.0003820119,0.9283444,0.0001513632,0.001184751,0.01939634],"study_design_scores_gemma":[0.005536564,0.3885665,0.2628095,0.000132771,0.0004296444,0.001450863,0.001003401,0.001501987,0.3306527,0.00009312462,0.007759373,0.00006371063],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977189,0.0006488798,0.0004771152,0.0000430478,0.00001367071,0.0002361448,0.0002339137,0.00002171218,0.0006066022],"genre_scores_gemma":[0.9971662,0.0005502118,0.0006588546,0.0001010867,0.00001044854,0.0002574065,0.00044521,0.000006482173,0.0008040132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00355515,"threshold_uncertainty_score":0.007068932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220151018192552,"score_gpt":0.2872415680813064,"score_spread":0.2750400578993809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}