{"id":"W7118803318","doi":"10.30683/1929-2279.2025.14.26","title":"A Repurposed Duo: Empagliflozin-Metformin Triggers a Metabolic Crisis in Cervical Cancer by Disrupting the Acyl-CoA/CoA Ratio via Dual Inhibition of PPAT and CPT1A","year":2025,"lang":"","type":"article","venue":"Journal of cancer research updates","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mustansiriyah University; University of Baghdad","keywords":"HeLa; MTT assay; Docking (animal); Empagliflozin; Intracellular; Combination therapy; Cytotoxicity","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030609,0.0002682891,0.0003555986,0.0002276748,0.0001190874,0.0002248983,0.0002047955,0.0002499865,0.000836386],"category_scores_gemma":[0.00008813004,0.0001008185,0.0002683428,0.0001606418,0.0001287705,0.000199186,0.0001996174,0.0004512072,0.0001529772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000290764,"about_ca_system_score_gemma":0.0001834376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006268895,"about_ca_topic_score_gemma":0.001253253,"domain_scores_codex":[0.9999058,0.00001101101,0.000007418909,0.0000241824,0.00003342445,0.0000181992],"domain_scores_gemma":[0.9999764,0.000003282663,0.000007765539,0.000002378419,0.000003438669,0.000006735419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005776981,0.0001014221,0.0005688852,0.00014078,0.000032501,0.0001116197,0.00001697785,0.0003105972,0.9897848,0.0001093374,0.0001638241,0.008081577],"study_design_scores_gemma":[0.0000655114,0.001477199,0.005570468,0.00001547887,0.000102525,0.0004924367,0.0000453343,0.00351409,0.9827133,0.00005488234,0.005938836,0.000009971644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922385,0.004177344,0.001995011,0.0001773489,0.0000483594,0.00003240528,0.0002515819,0.00006068607,0.001018739],"genre_scores_gemma":[0.993893,0.001795818,0.002598488,0.0001017895,0.0000114324,0.00004235634,0.0003204277,0.000007878488,0.001228894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000836386,"threshold_uncertainty_score":0.002797961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193978494488315,"score_gpt":0.3706679973894287,"score_spread":0.3512701479405972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}