{"id":"W7118913944","doi":"10.1002/alz70856_106425","title":"White Matter Hyperintensities on Brain MRI are Related to Brain Atrophy and Accelerated Brain Age","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"British Columbia Academic Health Science Network","funders":"","keywords":"Hyperintensity; Neuroimaging; Fluid-attenuated inversion recovery; Atrophy; White matter; Brain size; Brain aging; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005416111,0.0003377325,0.0002686613,0.0008708266,0.0002217992,0.0004252031,0.0002117436,0.0003473294,0.001874798],"category_scores_gemma":[0.002336164,0.0002051109,0.000208651,0.0005016314,0.0002707103,0.0003859291,0.0003781107,0.0003287858,0.0002481054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001435899,"about_ca_system_score_gemma":0.000157276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003026747,"about_ca_topic_score_gemma":0.004342388,"domain_scores_codex":[0.9998091,0.00003058678,0.00002122572,0.00008241185,0.00003256714,0.00002414522],"domain_scores_gemma":[0.9987569,0.0001614902,0.0006889844,0.0001102419,0.0001877681,0.00009456192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000848632,0.00008572338,0.982536,0.00007679609,0.0002399293,0.000199426,0.0001874136,0.000389089,0.004151329,0.0001160565,0.0006156952,0.01055391],"study_design_scores_gemma":[0.000003595012,0.00005565258,0.9985057,0.000007986112,0.00003603252,0.0002446051,0.0000492984,0.0003875849,0.0003513144,0.0001731274,0.0001818928,0.000003337009],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981401,0.0005352322,0.000313123,0.00003993818,0.00000833641,0.000008637583,0.0004382531,0.00001839505,0.0004979235],"genre_scores_gemma":[0.998672,0.0001790306,0.0003369062,0.00002052724,0.00001542205,0.000008298405,0.0004761782,0.000006121189,0.0002855095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003026747,"threshold_uncertainty_score":0.006271839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0216320154943407,"score_gpt":0.3080083715880961,"score_spread":0.2863763560937554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}