{"id":"W7119493465","doi":"10.1002/alz70856_106526","title":"STIP1 Knockout Mitigates Disease Progression in a Synucleinopathy Mouse Model: A Multimodal Behavioral and Neuroimaging Study","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University; McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Neurodegeneration; Knockout mouse; Genetically modified mouse; Cognition; Disease; Neuroimaging; Striatum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004389771,0.001233199,0.0008001373,0.000886292,0.0003834981,0.0004524316,0.0004367911,0.0008420668,0.00208655],"category_scores_gemma":[0.0001265643,0.0003272356,0.0006193719,0.0002664537,0.0006210163,0.0006241329,0.0003644787,0.001586542,0.0005500312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000520328,"about_ca_system_score_gemma":0.0004160852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009015,"about_ca_topic_score_gemma":0.002245996,"domain_scores_codex":[0.9998012,0.00001783243,0.000019021,0.00006711495,0.00004411268,0.00005071463],"domain_scores_gemma":[0.9997086,0.0000110367,0.0000845978,0.00002014557,0.00005476905,0.0001207203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001359937,0.0008242244,0.0007653843,0.0001636564,0.00005506115,0.0002051633,0.00006523134,0.0002076633,0.9910197,0.0001519643,0.0003751346,0.004806927],"study_design_scores_gemma":[0.0004406939,0.01609433,0.03124776,0.0001945985,0.0005824893,0.001780846,0.0004230869,0.004297983,0.937332,0.0007205319,0.006806835,0.00007882579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868171,0.002051255,0.006096481,0.0004315421,0.0001188987,0.0002157928,0.001851114,0.0004880918,0.001929776],"genre_scores_gemma":[0.9736984,0.0036313,0.008647452,0.0003857178,0.00005813175,0.0006762177,0.002756465,0.0001275601,0.01001866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00208655,"threshold_uncertainty_score":0.006980181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02513834464352405,"score_gpt":0.32487378946657,"score_spread":0.2997354448230459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}