{"id":"W7119515219","doi":"10.1093/ibd/izaf322","title":"Efficacy, Safety, and Pharmacokinetics of Golimumab in Children with Moderately-To-Severely Active Ulcerative Colitis: Results from the PURSUIT 2 Study","year":2025,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Johnson and Johnson","keywords":"Golimumab; Pharmacokinetics; Ulcerative colitis; Active metabolite; MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001719209,0.0004090869,0.0007789633,0.0001680367,0.0001975588,0.000349085,0.0002058309,0.000325166,0.0005999809],"category_scores_gemma":[0.001336916,0.0001682159,0.0009538956,0.0002472581,0.0003365845,0.0003408878,0.0003522131,0.0008060091,0.0001569746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004063263,"about_ca_system_score_gemma":0.0007003333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007290533,"about_ca_topic_score_gemma":0.0008603234,"domain_scores_codex":[0.9993358,0.0003804355,0.0000555044,0.00006254982,0.0001044771,0.00006114796],"domain_scores_gemma":[0.9984397,0.0004153232,0.0005708706,0.0001086348,0.0001332919,0.0003321369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3214731,0.01465192,0.4859651,0.0008959084,0.002547609,0.001171592,0.001391453,0.003032802,0.03631594,0.0002337268,0.002883988,0.1294369],"study_design_scores_gemma":[0.05362958,0.2616357,0.6702589,0.00008389612,0.001207882,0.001843732,0.0002624382,0.001315156,0.004817584,0.0000801537,0.004815462,0.00004946799],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983192,0.0006938923,0.0001082175,0.00006231338,0.000004002235,0.00008782501,0.0003936142,0.000007050066,0.0003238628],"genre_scores_gemma":[0.99714,0.0005981373,0.0005358157,0.0001145025,0.00002838414,0.0001331881,0.001251336,0.000006124058,0.0001924543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001719209,"threshold_uncertainty_score":0.009092152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006220005657984788,"score_gpt":0.2485502067183567,"score_spread":0.242330201060372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}