{"id":"W7119526442","doi":"10.1002/alz70856_107283","title":"Mapping molecular pathways underlying the relationship between plasma ptau and Alzheimer's disease pathology: an imaging‐transcriptomic study","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; Montreal Neurological Institute and Hospital; University of Toronto; Health Sciences Centre; Sunnybrook Hospital; McGill University; Artificial Intelligence in Medicine (Canada); Ontario Brain Institute; Heart and Stroke Foundation; McGill University Health Centre; Sunnybrook Health Science Centre","funders":"","keywords":"KEGG; Transcriptome; Disease; Partial least squares regression; Gene; Analysis of variance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002434772,0.0002792455,0.0003809375,0.0006159918,0.0003006338,0.0005835966,0.0001499658,0.0002680544,0.001539005],"category_scores_gemma":[0.0004425386,0.0001358906,0.0004171875,0.0009177441,0.0002508254,0.0002121793,0.000259139,0.0002385827,0.0003010064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000297567,"about_ca_system_score_gemma":0.0003562586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002149995,"about_ca_topic_score_gemma":0.003086633,"domain_scores_codex":[0.9998579,0.000020363,0.000006626058,0.00007166373,0.00001809601,0.00002522824],"domain_scores_gemma":[0.9997682,0.0000574252,0.00008919332,0.00002063032,0.00003877888,0.00002581381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003774946,0.0002180449,0.4803708,0.0008985405,0.001134059,0.0009294161,0.0006807839,0.001783899,0.4645185,0.0007316084,0.001978012,0.04298132],"study_design_scores_gemma":[0.0000462828,0.0002670426,0.975615,0.00004759399,0.0004728053,0.0007902288,0.000353172,0.003463252,0.01526775,0.001285979,0.002365232,0.00002554152],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881242,0.002034531,0.003104118,0.0001409813,0.00001041797,0.00002913116,0.005834749,0.00004989416,0.0006720684],"genre_scores_gemma":[0.9912544,0.0007861507,0.002906571,0.0001059357,0.00001821714,0.00007494206,0.003901786,0.00001742294,0.0009345757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002149995,"threshold_uncertainty_score":0.00514847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08768755352889615,"score_gpt":0.3465215109449469,"score_spread":0.2588339574160508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}