{"id":"W7119959280","doi":"10.1002/alz70856_107663","title":"Imaging‐based biological staging associates with brain atrophy in preclinical Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Disease; Atrophy; Neuroimaging; Stage (stratigraphy); Isolated brain; Human brain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008882982,0.0005418964,0.0003532374,0.00100397,0.0003021879,0.0005359095,0.0003744317,0.0005043179,0.001715025],"category_scores_gemma":[0.002599931,0.0001700602,0.0002413632,0.0006314206,0.0003924308,0.0004542782,0.0003859218,0.0004190619,0.0002385055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001465173,"about_ca_system_score_gemma":0.0001772423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009783901,"about_ca_topic_score_gemma":0.0009151702,"domain_scores_codex":[0.9997205,0.00008938313,0.00004015028,0.00006779299,0.00004810995,0.00003402922],"domain_scores_gemma":[0.9976762,0.0004573003,0.001221002,0.0001381242,0.0002561578,0.000251301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000754271,0.0001135799,0.9946263,0.00001739046,0.00006124453,0.00009049267,0.00005393432,0.00005533738,0.002339999,0.00002850888,0.00004890287,0.001810131],"study_design_scores_gemma":[0.00001123256,0.0002455971,0.9989371,0.000003704446,0.00002524143,0.0002641907,0.00003490863,0.0001477015,0.0002064574,0.00007278928,0.00004903095,0.000002011746],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988696,0.0003878502,0.0001539383,0.00002540526,0.000004053523,0.000008833029,0.0001096229,0.000004985691,0.0004356938],"genre_scores_gemma":[0.9995358,0.00006395252,0.0001389553,0.000008405939,0.00001172091,0.000006859197,0.0001332185,0.000001605097,0.00009960025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715025,"threshold_uncertainty_score":0.005737364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03860703420353377,"score_gpt":0.3586901096452422,"score_spread":0.3200830754417084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}