{"id":"W7120013993","doi":"10.1002/alz70856_107489","title":"Population enrichment strategy using <i>APOE</i> ε4 genotype in tau‐targeting trials for preclinical Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Disease; Genotype; Asymptomatic; Population; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05432285,0.001160049,0.002046431,0.002462124,0.001029982,0.001304302,0.001618808,0.001558408,0.007230539],"category_scores_gemma":[0.120751,0.0004849813,0.003137616,0.001281401,0.0009747294,0.0007630035,0.001391591,0.0009543815,0.000728782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006336002,"about_ca_system_score_gemma":0.003082151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002021891,"about_ca_topic_score_gemma":0.002210608,"domain_scores_codex":[0.9397948,0.0516135,0.002239351,0.003075266,0.002262552,0.001014586],"domain_scores_gemma":[0.9151671,0.07385742,0.002433105,0.00398642,0.003469846,0.001086195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.04551954,0.003019556,0.400984,0.002493417,0.0262919,0.003070577,0.001482281,0.06124782,0.0182513,0.01074509,0.01183381,0.4150608],"study_design_scores_gemma":[0.01001855,0.01904076,0.2114367,0.0007033062,0.02530802,0.001999925,0.000810817,0.6671385,0.01554903,0.02555165,0.0221599,0.0002828199],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5346038,0.002041312,0.4412514,0.001917269,0.0005536278,0.01113135,0.001861206,0.001319482,0.005320545],"genre_scores_gemma":[0.8868532,0.0001680278,0.1022053,0.0006561681,0.00008818198,0.007087189,0.0008676275,0.00007652343,0.001997802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05432285,"threshold_uncertainty_score":0.2872902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1390977546319474,"score_gpt":0.4254665933980866,"score_spread":0.2863688387661393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}