{"id":"W7120115505","doi":"10.1002/alz70856_107452","title":"Imaging‐based Biological Staging for Alzheimer's Disease Prognosis","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Disease; Risk stratification; Staging system; Stage (stratigraphy); Magnetic resonance imaging; Positron emission tomography; Medical imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003443159,0.0007576903,0.0004911871,0.001551506,0.0002510733,0.000783466,0.000631671,0.0003257596,0.00144548],"category_scores_gemma":[0.005820832,0.0001037019,0.0004226604,0.0007097823,0.0003702992,0.0005579351,0.0004786872,0.0004069647,0.0003344475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000336922,"about_ca_system_score_gemma":0.0004230378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002232055,"about_ca_topic_score_gemma":0.002249214,"domain_scores_codex":[0.9992858,0.0003585093,0.00009256462,0.0001006377,0.0001073579,0.00005527855],"domain_scores_gemma":[0.9970366,0.0007571008,0.001084887,0.0002454241,0.000637062,0.0002389755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007774047,0.00004592814,0.9711192,0.00006560575,0.0001560579,0.00007754273,0.00005338596,0.0009012086,0.000691268,0.0002505434,0.0009915479,0.02487036],"study_design_scores_gemma":[0.00009512216,0.0007705692,0.9792179,0.0001407714,0.0002911291,0.0008753638,0.0001364166,0.01196044,0.001736395,0.001616612,0.00312333,0.00003601241],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763159,0.007174043,0.008748429,0.0004534922,0.0001123105,0.0001274129,0.002201764,0.0001453766,0.004721362],"genre_scores_gemma":[0.9952328,0.000506953,0.002857043,0.0000448235,0.00007491891,0.00005900192,0.0008258762,0.000008007322,0.0003906031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003443159,"threshold_uncertainty_score":0.0182094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04420345133235216,"score_gpt":0.3494530545628326,"score_spread":0.3052496032304804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}