{"id":"W7125837415","doi":"10.17504/protocols.io.261ge16oyv47/v1","title":"Site-Directed Mutagenesis v1","year":2025,"lang":"","type":"article","venue":"","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Gene; Mutagenesis; Genetic variants; Mutation; Site-directed mutagenesis; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002442312,0.002155785,0.001699836,0.001229137,0.0008863393,0.001026528,0.002558331,0.001594996,0.0316611],"category_scores_gemma":[0.001472323,0.002200429,0.001459853,0.000953207,0.0006480094,0.0005254972,0.0009140156,0.003299736,0.02742107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007070754,"about_ca_system_score_gemma":0.001305841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001541845,"about_ca_topic_score_gemma":0.003381165,"domain_scores_codex":[0.9968461,0.0007365828,0.0003407141,0.0008719086,0.0007086015,0.00049602],"domain_scores_gemma":[0.9986486,0.0004352557,0.00009864698,0.0005125942,0.0001927651,0.0001121796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000477178,0.0002876282,0.0003439467,0.0005304906,0.00007598239,0.0003287381,0.000117026,0.000551147,0.9624349,0.004292473,0.01020711,0.0203534],"study_design_scores_gemma":[0.0001940904,0.000506048,0.001442496,0.0001161209,0.0001129684,0.001551736,0.00006705333,0.002655543,0.8465746,0.0009333934,0.1457458,0.0001002058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1091011,0.002753124,0.7636582,0.001112617,0.001685567,0.01043997,0.02884173,0.0214364,0.0609712],"genre_scores_gemma":[0.3051682,0.003918286,0.4347864,0.001637224,0.0001668519,0.009151726,0.08115324,0.01055469,0.1534634],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.0316611,"threshold_uncertainty_score":0.1059169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003083624064368579,"score_gpt":0.2272659247581651,"score_spread":0.2241823006937965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}