{"id":"W7126002792","doi":"","title":"Long-term tofersen in SOD1 amyotrophic lateral sclerosis","year":2025,"lang":"en","type":"article","venue":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Leonard M. Miller School of Medicine; Faculty of Medicine and Health, University of Sydney; School of Medicine, Emory University; University of Miami; Universität Ulm; KU Leuven; Assistance Publique - Hôpitaux de Paris; Università degli Studi di Torino; Emory University; King's College London; McGill University; Biogen","keywords":"SOD1; Amyotrophic lateral sclerosis; Placebo; Superoxide dismutase; Clinical trial; Neurodegeneration; Riluzole; Intervention (counseling)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001844098,0.0003352568,0.0009229568,0.0001627124,0.000287954,0.0003395271,0.0003346118,0.0006382765,0.001591565],"category_scores_gemma":[0.001451796,0.0001370284,0.0008125273,0.0001914881,0.0004794853,0.0004431304,0.0003171128,0.0007424746,0.0001660188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003395422,"about_ca_system_score_gemma":0.0004324091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005354706,"about_ca_topic_score_gemma":0.00165849,"domain_scores_codex":[0.9992992,0.0003708313,0.00008637777,0.00007905799,0.00009184787,0.00007273051],"domain_scores_gemma":[0.999122,0.0002794487,0.0002838751,0.00004684929,0.00006319847,0.0002046385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5863018,0.01496453,0.07885273,0.00362928,0.0030765,0.0005630453,0.0002945395,0.001021776,0.0164051,0.0004378979,0.002326802,0.2921259],"study_design_scores_gemma":[0.123302,0.6459725,0.2117842,0.0008389602,0.002556817,0.001164579,0.0002701687,0.0008686307,0.004900535,0.0007271954,0.007558329,0.00005609641],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791382,0.01824891,0.0003137882,0.0003240347,0.0001151569,0.0002164624,0.0003977737,0.00002287669,0.001222771],"genre_scores_gemma":[0.9942235,0.003728523,0.0004092734,0.0002980451,0.0001196733,0.0001977374,0.0004159033,0.000002739095,0.0006045906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001844098,"threshold_uncertainty_score":0.009752631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06110571275986014,"score_gpt":0.2932942208482345,"score_spread":0.2321885080883743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}