{"id":"W7127580107","doi":"10.1093/eurheartj/ehaf784.1164","title":"A proteo-genomic discovery approach to identify markers of early heart failure","year":2025,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"","keywords":"Heart failure; Heart disease; Genome-wide association study; Prospective cohort study; Genetic predisposition; Epidemiology; Heart failure with preserved ejection fraction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001830464,0.0005205292,0.0004846301,0.003117276,0.0005980027,0.0007584124,0.0004390405,0.000388728,0.001035381],"category_scores_gemma":[0.002748406,0.0001969023,0.0006391841,0.001831847,0.0003746389,0.0002100761,0.0009273585,0.0005397936,0.0002357087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002861234,"about_ca_system_score_gemma":0.0006939592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001582943,"about_ca_topic_score_gemma":0.002351936,"domain_scores_codex":[0.9992748,0.0003207284,0.0000396862,0.0001877819,0.0001013708,0.00007561603],"domain_scores_gemma":[0.9988596,0.0004240113,0.0002925752,0.0001560646,0.0001583511,0.0001094082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009476336,0.000664133,0.7627621,0.0003148073,0.001484908,0.001259859,0.0003966835,0.003567567,0.1230516,0.002501137,0.002675786,0.1003738],"study_design_scores_gemma":[0.0001174055,0.0008226368,0.9324178,0.00004479304,0.0008608926,0.002182368,0.0003927166,0.0406655,0.0105627,0.006225253,0.005654792,0.00005316618],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9467598,0.001623062,0.04470972,0.001007508,0.00006317013,0.0002565906,0.002615328,0.0002890213,0.002675788],"genre_scores_gemma":[0.9685888,0.0002561881,0.0287304,0.0002672977,0.00005495113,0.0001496149,0.001236881,0.00001987247,0.0006958979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003117276,"threshold_uncertainty_score":0.00968051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260195247767291,"score_gpt":0.2986930518740905,"score_spread":0.2726735270973614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}