{"id":"W7127607721","doi":"10.1093/eurheartj/ehaf784.3721","title":"BW-00112 targeting ANGPTL3 results in prolonged reductions in plasma triglycerides, LDL-C, and remnant-C in Chinese healthy subjects","year":2025,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Debiopharm Group (Canada)","funders":"","keywords":"Tolerability; Adverse effect; Pharmacokinetics; Pharmacodynamics; Lipoprotein; Lipid profile; Lipoprotein lipase; Lipid metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002248814,0.0002934965,0.0005438762,0.00013682,0.0002298619,0.0001571877,0.0001585515,0.0002706231,0.001598934],"category_scores_gemma":[0.000103877,0.0001262754,0.0003373847,0.0001295489,0.0002287809,0.0001329042,0.000120952,0.0004518016,0.0002292056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002396866,"about_ca_system_score_gemma":0.0004008808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002464216,"about_ca_topic_score_gemma":0.002967248,"domain_scores_codex":[0.9999051,0.00001280166,0.00000889023,0.00002788173,0.0000231737,0.00002216283],"domain_scores_gemma":[0.999946,0.000004853132,0.00001086298,0.000005184294,0.000009081963,0.00002407359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01777394,0.003220518,0.01118343,0.0004090842,0.0001864905,0.0004170874,0.0002100778,0.0003075782,0.9328731,0.0001015519,0.000909122,0.03240807],"study_design_scores_gemma":[0.008524573,0.1982628,0.3028316,0.00004846629,0.001268876,0.002639137,0.0005170511,0.006933864,0.4659394,0.0002796943,0.01261499,0.000139727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985751,0.0004361839,0.0003308935,0.00005293391,0.00001579288,0.00004734023,0.0001269109,0.00002498469,0.0003898302],"genre_scores_gemma":[0.9969633,0.0002649636,0.0004341356,0.0001240444,0.000009799479,0.00008907467,0.0001799697,0.000006293182,0.001928429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002464216,"threshold_uncertainty_score":0.005348921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02031586893907366,"score_gpt":0.3097178819259871,"score_spread":0.2894020129869134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}