{"id":"W7127987629","doi":"10.1093/eurheartj/ehaf784.2750","title":"Effectiveness and safety of edge-to-edge MItral vaLve repair in patients with significant mitraL rEgurgitatioN aNd cardIac ATTR amyloidosis: design and rationale of the MILLENNIAL trial","year":2025,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"","keywords":"Concomitant; Mitral valve repair; Mitral regurgitation; Heart failure; Randomized controlled trial; Clinical endpoint; Randomization; Dilated cardiomyopathy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02026108,0.002787195,0.005148408,0.0006640599,0.000811681,0.002540276,0.001809982,0.003565999,0.007342426],"category_scores_gemma":[0.01472102,0.0008582592,0.004259355,0.0006754601,0.002839085,0.002405475,0.00165549,0.003264867,0.00118042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007175468,"about_ca_system_score_gemma":0.001127785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001860676,"about_ca_topic_score_gemma":0.0002399594,"domain_scores_codex":[0.9876738,0.009597112,0.0006809679,0.001125417,0.0004546905,0.0004679862],"domain_scores_gemma":[0.9926202,0.003606343,0.001349948,0.0009424634,0.0004525298,0.001028644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9772594,0.004449091,0.00237545,0.002192569,0.002507607,0.00007559665,0.00009577533,0.0006439352,0.001216861,0.001107681,0.0007281105,0.007347956],"study_design_scores_gemma":[0.902858,0.08235232,0.002716655,0.0003514539,0.003479991,0.00007338096,0.00007934873,0.00153352,0.0007240832,0.003067123,0.002701532,0.00006247385],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8727264,0.01692491,0.009218195,0.003996514,0.003057644,0.08038947,0.003113156,0.0001561971,0.01041752],"genre_scores_gemma":[0.8770223,0.002223571,0.01377642,0.003137745,0.002155273,0.09694789,0.001459908,0.00004947077,0.003227308],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.02026108,"threshold_uncertainty_score":0.1071521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0118448564839815,"score_gpt":0.2514816421399365,"score_spread":0.239636785655955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}