{"id":"W7128077415","doi":"10.1093/eurheartj/ehaf784.2740","title":"Acoramidis has a beneficial effect compared with placebo on change from baseline in NAC ATTR stage at month 30 in patients with ATTR-CM: results from the ATTRibute-CM study","year":2025,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Calgary","funders":"","keywords":"Placebo; Transthyretin; Randomized controlled trial; Stage (stratigraphy); Heart failure; Clinical trial; Renal function; Amyloidosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001647765,0.0009104216,0.002423011,0.0003273252,0.0002821021,0.000638021,0.0005293642,0.001212632,0.003104802],"category_scores_gemma":[0.001637071,0.000277623,0.002381367,0.0002677076,0.0005546715,0.0005528213,0.0003493632,0.001518012,0.0003036576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003016876,"about_ca_system_score_gemma":0.0004913304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004394754,"about_ca_topic_score_gemma":0.001250656,"domain_scores_codex":[0.9993225,0.0003466973,0.00007277793,0.0001176611,0.00007810644,0.00006220338],"domain_scores_gemma":[0.9984046,0.0004396667,0.0005122919,0.0001081035,0.0001126921,0.0004227593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9538049,0.008389113,0.004989936,0.0007066723,0.002395674,0.00005505193,0.00005776121,0.0002245169,0.006909025,0.00004284792,0.0004329412,0.02199152],"study_design_scores_gemma":[0.588754,0.3414722,0.06160218,0.00009844945,0.003968537,0.00014314,0.00008139244,0.0008169733,0.002015556,0.0001874217,0.0008113711,0.00004884238],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939218,0.004379342,0.0001157515,0.000173901,0.000128547,0.0002437302,0.0004270661,0.0000311828,0.0005787781],"genre_scores_gemma":[0.9967824,0.00127946,0.0003891868,0.0002479953,0.0002523855,0.0002053093,0.0003575065,0.000004612402,0.0004811749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003104802,"threshold_uncertainty_score":0.01038659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03735448569341315,"score_gpt":0.2791445441648615,"score_spread":0.2417900584714483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}