{"id":"W7128613288","doi":"10.1093/ibd/izaf329","title":"Primary infliximab failure in pediatric colonic inflammatory bowel disease: Development of a proteomics predictive model using a prospective Canadian cohort","year":2025,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Alberta Children's Hospital; Children's Hospital Research Institute of Manitoba; University of Alberta; Institute for Clinical Evaluative Sciences; Children's Hospital of Eastern Ontario; Hospital for Sick Children; Institute for Work & Health; BC Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine; Dalhousie University; University of Toronto","funders":"Janssen Biotech; Canadian Institutes of Health Research","keywords":"Proteomics; Infliximab; Cohort; Prospective cohort study; Inflammatory bowel disease; Cohort study; Inflammatory Bowel Diseases","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003570569,0.0008562433,0.0005819111,0.001228561,0.001203003,0.0008881988,0.001219676,0.0004671348,0.001267999],"category_scores_gemma":[0.004574668,0.0003568191,0.001047769,0.0009297605,0.0004194727,0.0002926892,0.0006969865,0.0009333587,0.0002458031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006408701,"about_ca_system_score_gemma":0.00831623,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7924726,"about_ca_topic_score_gemma":0.6686599,"domain_scores_codex":[0.9995103,0.0001272899,0.00002612739,0.0001527817,0.00009842646,0.00008515039],"domain_scores_gemma":[0.9982556,0.0005609858,0.0002432039,0.0001569392,0.0005493547,0.0002340065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006683973,0.00009897679,0.9624015,0.00002940302,0.0002869399,0.0002553567,0.000166521,0.02159302,0.0004223656,0.000289511,0.001139981,0.01264814],"study_design_scores_gemma":[0.0002194796,0.0004002072,0.5186151,0.00005356423,0.0004980658,0.0004369028,0.000470035,0.4759229,0.0005421593,0.0004525052,0.002323923,0.00006508222],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931735,0.0001872258,0.004082328,0.00024286,0.00001332401,0.00009514744,0.001610278,0.00004405116,0.0005512186],"genre_scores_gemma":[0.9925171,0.0001846026,0.004667416,0.00003413111,0.000008546273,0.00005194337,0.002137271,0.00001414247,0.0003848661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2075274,"threshold_uncertainty_score":0.4174991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00477459433200582,"score_gpt":0.2170562572215648,"score_spread":0.212281662889559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}