{"id":"W7131221479","doi":"10.1210/jcemcr/luaf279","title":"Exceptional Response to a Single Dose of Pembrolizumab as Salvage Therapy for Metastatic Adrenocortical Carcinoma","year":2025,"lang":"en","type":"article","venue":"JCEM Case Reports","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"","keywords":"Pembrolizumab; Salvage therapy; Mitotane; Hypermetabolism; Progressive disease; Adrenocortical carcinoma; Lung; Biopsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004673642,0.0001709245,0.0004318176,0.0002489504,0.00007284811,0.0000113687,0.0000289522,0.00005792216,0.0002572387],"category_scores_gemma":[0.0007687557,0.0001372042,0.000223361,0.0003376782,0.00007160975,0.00003811528,0.00003513608,0.0001015008,0.000009911585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009442178,"about_ca_system_score_gemma":0.000650425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007618579,"about_ca_topic_score_gemma":0.000009769768,"domain_scores_codex":[0.9984089,0.00007796528,0.0006268839,0.000353404,0.0002705162,0.0002623048],"domain_scores_gemma":[0.9986286,0.0003618237,0.000157319,0.0004276299,0.0002141167,0.0002105136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.04581669,0.00171278,0.002020313,0.0003533774,0.0003721684,0.881411,0.001051301,0.00005123494,0.04832558,0.001071365,0.007219366,0.01059485],"study_design_scores_gemma":[0.007476759,0.004695214,0.07424454,0.0003143877,0.000487591,0.8396461,0.0003745692,0.0001847284,0.05490132,0.003252389,0.01404125,0.0003811411],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949967,0.0003525384,0.001079989,0.001147986,0.0001807822,0.001120929,0.00002257419,0.00004232479,0.001056143],"genre_scores_gemma":[0.9932637,0.000001310261,0.001346379,0.0008620689,0.00007810108,0.0001276349,0.00002885847,0.00002112384,0.004270851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07222424,"threshold_uncertainty_score":0.5595023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03271006343782597,"score_gpt":0.3391139443235011,"score_spread":0.3064038808856752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}