{"id":"W7131757302","doi":"","title":"HLA-A03:01 as predictive genetic biomarker for glatiramer acetate treatment response in multiple sclerosis: a retrospective cohort analysis","year":2025,"lang":"","type":"article","venue":"MPG.PuRe (Max Planck Society)","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk; Heinrich-Heine-Universität Düsseldorf; Sanofi Genzyme; EMD Serono; National Institutes of Health; Bundesministerium für Bildung und Forschung; Valhalla Foundation; Deutsche Forschungsgemeinschaft; Deutschen Multiple Sklerose Gesellschaft; Bayer Vital; Deutscher Akademischer Austauschdienst; Multiple Sclerosis Society; Biogen; Moderna; Bundesinstitut für Risikobewertung; Chugai Pharmaceutical; Guthy-Jackson Charitable Foundation; University of California, San Francisco; Alzheimer Society; NGM Biopharmaceuticals; Adaptive Biotechnologies; Fresenius Medical Care North America; H. Lundbeck A/S; Baxalta; Sanofi; TG Therapeutics; Genentech; Gemeinsame Bundesausschuss; Japan Society for the Promotion of Science; Deutsche Alzheimer Gesellschaft; Max-Planck-Gesellschaft; Amicus Therapeutics; University of Bern; Argenx; Daimler und Benz Stiftung; Novartis; Celgene; Grifols; F. Hoffmann-La Roche; Alexion Pharmaceuticals; Gilead Sciences; Neuraxpharm; Bristol-Myers Squibb; Teva Pharmaceutical Industries; CSL Behring; Eli Lilly and Company; Samsung; Novo Nordisk Pharma; Amgen","keywords":"Glatiramer acetate; Cohort; Multiple sclerosis; Retrospective cohort study; Biomarker; Human leukocyte antigen; Biosimilar; Pharmacogenetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.002443975,0.0017398,0.004000247,0.001580384,0.001193154,0.0002919801,0.0007323739,0.001148916,0.0005432957],"category_scores_gemma":[0.005194454,0.001579626,0.003268951,0.007509353,0.001405845,0.0003086679,0.0005954518,0.001195031,0.0001066773],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007093443,"about_ca_system_score_gemma":0.001690999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001555403,"about_ca_topic_score_gemma":0.001667307,"domain_scores_codex":[0.9884362,0.001386981,0.002178948,0.003296815,0.001875149,0.002825886],"domain_scores_gemma":[0.9907002,0.004664643,0.0007153848,0.002005006,0.001180419,0.0007343173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03741951,0.002277693,0.8596554,0.0005157041,0.05369363,0.00007447806,0.00965107,0.001393768,0.01583429,0.000018541,0.01498734,0.004478543],"study_design_scores_gemma":[0.02094503,0.003666655,0.862131,0.001178018,0.009876129,0.000003267046,0.005558962,0.08961726,0.001497306,0.0001240035,0.004437268,0.0009650946],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606783,0.01104388,0.003142857,0.004076661,0.0009146414,0.01448158,0.003844035,0.000244209,0.00157387],"genre_scores_gemma":[0.9669713,0.01404019,0.003002092,0.0006438672,0.0004019462,0.006055546,0.0004903366,0.0001736114,0.00822114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08822349,"threshold_uncertainty_score":0.9995348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05228494536215954,"score_gpt":0.3236504991780784,"score_spread":0.2713655538159188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}