{"id":"W7131757302","doi":"","title":"HLA-A03:01 as predictive genetic biomarker for glatiramer acetate treatment response in multiple sclerosis: a retrospective cohort analysis","year":2025,"lang":"","type":"article","venue":"MPG.PuRe (Max Planck Society)","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk; Heinrich-Heine-Universität Düsseldorf; Sanofi Genzyme; EMD Serono; National Institutes of Health; Bundesministerium für Bildung und Forschung; Valhalla Foundation; Deutsche Forschungsgemeinschaft; Deutschen Multiple Sklerose Gesellschaft; Bayer Vital; Deutscher Akademischer Austauschdienst; Multiple Sclerosis Society; Biogen; Moderna; Bundesinstitut für Risikobewertung; Chugai Pharmaceutical; Guthy-Jackson Charitable Foundation; University of California, San Francisco; Alzheimer Society; NGM Biopharmaceuticals; Adaptive Biotechnologies; Fresenius Medical Care North America; H. Lundbeck A/S; Baxalta; Sanofi; TG Therapeutics; Genentech; Gemeinsame Bundesausschuss; Japan Society for the Promotion of Science; Deutsche Alzheimer Gesellschaft; Max-Planck-Gesellschaft; Amicus Therapeutics; University of Bern; Argenx; Daimler und Benz Stiftung; Novartis; Celgene; Grifols; F. Hoffmann-La Roche; Alexion Pharmaceuticals; Gilead Sciences; Neuraxpharm; Bristol-Myers Squibb; Teva Pharmaceutical Industries; CSL Behring; Eli Lilly and Company; Samsung; Novo Nordisk Pharma; Amgen","keywords":"Glatiramer acetate; Cohort; Multiple sclerosis; Retrospective cohort study; Biomarker; Human leukocyte antigen; Biosimilar; Pharmacogenetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001793465,0.000388879,0.0005086004,0.0007086772,0.0005709067,0.0008508677,0.0005389921,0.0005018089,0.00118299],"category_scores_gemma":[0.002426823,0.0004450896,0.0007996948,0.0009743162,0.0003645472,0.0003798612,0.0005699937,0.0007139393,0.0003108315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003449772,"about_ca_system_score_gemma":0.0003514894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003077595,"about_ca_topic_score_gemma":0.002794159,"domain_scores_codex":[0.998849,0.0002956332,0.0001023383,0.0004988082,0.0001472362,0.0001069904],"domain_scores_gemma":[0.9978192,0.000359644,0.0006815136,0.0006938096,0.0001912808,0.0002545861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001115226,0.00004774234,0.9960975,0.00001339163,0.0003526672,0.0001884716,0.00007763305,0.00007452417,0.0007432732,0.00002430263,0.0001785558,0.001086702],"study_design_scores_gemma":[0.00005632723,0.0003404369,0.9975767,0.000007890753,0.0002675332,0.0007462946,0.00009532004,0.0003657894,0.0001573532,0.00002646371,0.0003516204,0.000008142552],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989722,0.000217182,0.0001276879,0.00001245006,0.00000439318,0.00001530657,0.0004684417,0.000003668469,0.0001786707],"genre_scores_gemma":[0.9991228,0.00006751988,0.0001052241,0.00001921527,0.000006644882,0.00001499254,0.0005830366,0.000004560241,0.00007602751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003077595,"threshold_uncertainty_score":0.009484828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05228494536215954,"score_gpt":0.3236504991780784,"score_spread":0.2713655538159188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}