{"id":"W7131812083","doi":"10.5376/cge.2025.13.0021","title":"Bottlenecks and Breakthrough Pathways of CAR-T Cell Therapy in Solid Tumors","year":2025,"lang":"","type":"article","venue":"Cancer Genetics and Epigenetics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Cell therapy; Cell; Cancer therapy; Radiation therapy; Antibody therapy; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006148996,0.0005772063,0.001195692,0.0004326953,0.000140466,0.00008181565,0.0003236525,0.0004626551,0.0006527782],"category_scores_gemma":[0.00004687757,0.000591695,0.0001451881,0.0007855903,0.0009010413,0.00003021796,0.0003420932,0.0006198747,0.000002163608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001985083,"about_ca_system_score_gemma":0.001341539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035449,"about_ca_topic_score_gemma":0.0004253139,"domain_scores_codex":[0.9961367,0.0001791579,0.001150635,0.0009147695,0.0006398611,0.000978934],"domain_scores_gemma":[0.9978018,0.0002167004,0.0002426738,0.0008421301,0.0005234296,0.0003732345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007038416,0.0004768381,0.190211,0.001364926,0.0002914769,0.0000464298,0.004707379,0.0006862598,0.3277299,0.0001308549,0.0004204081,0.4732307],"study_design_scores_gemma":[0.009669797,0.002769069,0.2395919,0.001447472,0.0002824373,0.00001106522,0.001842266,0.006011159,0.6889389,0.002190598,0.04638042,0.0008649626],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7329635,0.2612441,0.0001137867,0.0005723862,0.0004954502,0.001006711,0.0001441885,0.000009235864,0.003450679],"genre_scores_gemma":[0.5856967,0.4103304,0.0002280084,0.0002929191,0.0001741176,0.00005014359,0.00000858641,0.00005505235,0.003164003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4723658,"threshold_uncertainty_score":0.9996535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0310972616995913,"score_gpt":0.3271175472467459,"score_spread":0.2960202855471545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}