{"id":"W7131832016","doi":"10.5376/cge.2025.13.0012","title":"Mechanisms and Therapeutic Strategies for Endocrine Resistance in Breast Cancer","year":2025,"lang":"","type":"article","venue":"Cancer Genetics and Epigenetics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Breast cancer; Acquired resistance; Cancer; Endocrine system; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001939812,0.0005601787,0.0005238066,0.000152857,0.000251648,0.000175859,0.0002535526,0.0005327409,0.00001493819],"category_scores_gemma":[0.00000906225,0.0005693343,0.0001154993,0.0002807494,0.0003689844,0.00000610002,0.0002238065,0.0002740171,4.060115e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007257571,"about_ca_system_score_gemma":0.0008105059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001066693,"about_ca_topic_score_gemma":0.0009663728,"domain_scores_codex":[0.9974335,0.00009836825,0.000562983,0.0009763031,0.000146944,0.0007818362],"domain_scores_gemma":[0.9989381,0.0000533618,0.0001651893,0.0004359489,0.0002071129,0.0002002662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002790774,0.0005033618,0.0318739,0.003920152,0.002177907,0.00003085684,0.00105799,0.005260233,0.6680923,0.03751817,0.001926368,0.2448481],"study_design_scores_gemma":[0.02275806,0.00253566,0.1468223,0.003889852,0.003623175,0.00007449026,0.003371941,0.01967802,0.3759502,0.1491874,0.266184,0.005924873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.447279,0.5428855,0.004654693,0.002411637,0.0007945218,0.001025836,0.0004795767,0.000009936679,0.000459301],"genre_scores_gemma":[0.6802381,0.3167409,0.001097126,0.0005322226,0.0001319944,0.0002712421,0.0000204747,0.00004914762,0.0009187816],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2921421,"threshold_uncertainty_score":0.9996758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007616732674393486,"score_gpt":0.2793367765627724,"score_spread":0.2717200438883789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}