{"id":"W7131844708","doi":"10.5376/jvr.2024.14.0011","title":"The Evolution of mRNA Vaccine Technology: A Comprehensive Review","year":2024,"lang":"","type":"article","venue":"Journal of Vaccine Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Messenger RNA; Immune system; DNA vaccination; Disease; Vaccination","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003365426,0.0002560582,0.0006228706,0.0006892748,0.0002432101,0.0000903992,0.001157976,0.0003315146,0.000096032],"category_scores_gemma":[0.001591488,0.0001634444,0.0004866656,0.001612452,0.0001484845,0.0000167988,0.0005392477,0.001503504,0.00005035107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002204847,"about_ca_system_score_gemma":0.001594381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000279467,"about_ca_topic_score_gemma":0.00002042807,"domain_scores_codex":[0.9962432,0.0005463245,0.001410344,0.000363793,0.0008259625,0.0006103222],"domain_scores_gemma":[0.992586,0.0002818282,0.0004493169,0.0007174107,0.005810442,0.0001550525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001140243,0.0002433995,0.0009174076,0.004310622,0.001517986,0.0001627085,0.00004467787,0.00002082245,0.5050146,0.0007694441,0.3829923,0.1028658],"study_design_scores_gemma":[0.0009520634,0.006208576,0.0006960474,0.01354227,0.0002780476,0.0008255785,0.001199248,0.0002231941,0.09461945,0.001366491,0.8798403,0.0002487473],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1642236,0.8181736,0.0001360286,0.01576909,0.0008387544,0.0003695587,0.00001395789,0.000003968944,0.0004714117],"genre_scores_gemma":[0.5581025,0.4404146,0.00004108318,0.0000398121,0.0007134946,0.000005689839,0.000002619628,0.00001920549,0.0006610326],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.496848,"threshold_uncertainty_score":0.666507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03592533612490954,"score_gpt":0.3885145220710462,"score_spread":0.3525891859461366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}