{"id":"W7131855427","doi":"10.5376/ijccr.2025.15.0025","title":"The Role of the SIRT3–FOXO3a Axis in Mitochondrial Homeostasis and Oxidative Stress: Insights into Septic Cardiomyopathy","year":2025,"lang":"","type":"article","venue":"International Journal of Clinical Case Reports","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Oxidative phosphorylation; Oxidative stress; Mitochondrion; Homeostasis; Cardiomyopathy; Oxidative metabolism; Heart failure; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005368518,0.0003536907,0.0004667437,0.0006139817,0.0003571323,0.0006668771,0.0003506847,0.001059933,0.001269276],"category_scores_gemma":[0.0005490918,0.0001224903,0.0004915806,0.0004739119,0.0009176264,0.0005882465,0.0006041189,0.0008690949,0.0002213459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004711425,"about_ca_system_score_gemma":0.0004570057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004163242,"about_ca_topic_score_gemma":0.0006191304,"domain_scores_codex":[0.9997595,0.00006051115,0.00002676759,0.00004166278,0.00004787866,0.00006355887],"domain_scores_gemma":[0.9997582,0.00006075497,0.00007356127,0.00002571524,0.00002638626,0.00005546652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004188586,0.0004970662,0.1348261,0.002074317,0.0005630916,0.2424787,0.001600823,0.001971002,0.3275617,0.03244388,0.006483145,0.2453118],"study_design_scores_gemma":[0.0005917141,0.002904475,0.2225094,0.001472844,0.001037335,0.4213089,0.004448763,0.009949297,0.08984637,0.05857025,0.1870913,0.0002693938],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7953428,0.1465375,0.01918308,0.01536549,0.001232937,0.0001225555,0.0003436034,0.0002471789,0.02162491],"genre_scores_gemma":[0.9785282,0.01522604,0.003027103,0.00106935,0.0005625361,0.00002791556,0.00009522102,0.00001159168,0.001452108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001269276,"threshold_uncertainty_score":0.004246175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01583013644976256,"score_gpt":0.3644477294886038,"score_spread":0.3486175930388413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}