{"id":"W7131869518","doi":"10.5376/cge.2025.13.0001","title":"Advances in Genetic Susceptibility Studies of Colorectal Cancer: From Single Genes to Polygenic","year":2025,"lang":"","type":"article","venue":"Cancer Genetics and Epigenetics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Genetic variants; Gene; Genetic predisposition; Single-nucleotide polymorphism; Population; Genetic variation; Genetic association","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003741509,0.001099532,0.002266638,0.0006520235,0.0002095032,0.00007037105,0.0007118859,0.0006254186,0.0003683593],"category_scores_gemma":[0.0003708042,0.001160016,0.000287051,0.001856306,0.00137845,0.00006676706,0.0009561573,0.0005396718,0.000007166525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001330277,"about_ca_system_score_gemma":0.002030843,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002558555,"about_ca_topic_score_gemma":0.03585302,"domain_scores_codex":[0.9932252,0.0002968585,0.002279133,0.0019962,0.000798703,0.001403918],"domain_scores_gemma":[0.9960954,0.0006370182,0.000541911,0.001102939,0.001021014,0.0006016888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008365532,0.0003531817,0.5196075,0.001244824,0.0005303418,0.00001198778,0.002673085,0.01179813,0.1053341,0.00001010625,0.0001906024,0.3574095],"study_design_scores_gemma":[0.003225446,0.002551152,0.5868985,0.003129164,0.001553335,0.0000025466,0.003005573,0.002438963,0.3823316,0.002114984,0.01154263,0.001206127],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5260392,0.467989,0.0002292826,0.0005014683,0.003275435,0.001290441,0.0004856282,0.00001816795,0.0001713888],"genre_scores_gemma":[0.5667023,0.4287353,0.00338012,0.0003223837,0.0003227314,0.0002973991,0.000008928791,0.00006927127,0.0001615449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3562034,"threshold_uncertainty_score":0.999085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03253343155837272,"score_gpt":0.3564731985613712,"score_spread":0.3239397670029984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}