{"id":"W7131891463","doi":"10.1093/noajnl/vdaf243","title":"Single-cell transcriptomic profiling of malignant peripheral nerve sheath tumors","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Malignant peripheral nerve sheath tumor; Stromal cell; Schwann cell; Transcriptome; Sarcoma; Nerve sheath neoplasm; Gene expression profiling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001280651,0.0002395678,0.0007013478,0.0001777128,0.00009665678,0.00001124325,0.000158172,0.0001173728,0.00006568454],"category_scores_gemma":[0.0001130675,0.0002018702,0.0002029602,0.0003080922,0.0002465928,0.000154656,0.00004165672,0.0002833845,0.000004824648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007069964,"about_ca_system_score_gemma":0.0002795364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006833618,"about_ca_topic_score_gemma":0.000005040674,"domain_scores_codex":[0.9982505,0.0001391566,0.0005888786,0.0004756978,0.0001803745,0.0003653786],"domain_scores_gemma":[0.9990537,0.0002631017,0.000173062,0.0003119519,0.00009620535,0.000101983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006959797,0.0005456622,0.02151903,0.0004155305,0.00002106058,0.0006198936,0.0001011974,0.00004075699,0.9705263,0.0007686642,0.0003598436,0.004386114],"study_design_scores_gemma":[0.002279135,0.002762584,0.003363461,0.0001910629,0.0001427683,0.0004007103,0.0003548387,0.0001555144,0.9586402,0.0001967626,0.03134654,0.0001664385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808967,0.002803052,0.0001601729,0.001110075,0.0007954882,0.0005183181,0.00001704486,0.0001001465,0.01359897],"genre_scores_gemma":[0.9947831,0.0001581551,0.00336608,0.001157918,0.0000794452,0.00004606666,0.00001075865,0.00002725969,0.0003712231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0309867,"threshold_uncertainty_score":0.8232029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01857071478367243,"score_gpt":0.2830998552327428,"score_spread":0.2645291404490703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}