{"id":"W7132492668","doi":"","title":"The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging","year":2025,"lang":"en","type":"article","venue":"DZNE Pub","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; National Institute of Neurological Disorders and Stroke; National Institute on Aging; School of Public Health, Imperial College London; Instituto de Salud Carlos III; National Center for Advancing Translational Sciences; Medical Research Council; Wu Tsai Neurosciences Institute, Stanford University; Parkinsonfonden; University of California, San Francisco; School of Medicine, Emory University; National Institutes of Health; Université de Montréal; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Skånes universitetssjukhus; Alzheimer Nederland; Knut och Alice Wallenbergs Stiftelse; Janssen Research and Development; Generalitat de Catalunya; School of Medicine, Indiana University; Helsingin Yliopisto; GHR Foundation; European Commission; Sun Health Foundation; Vanderbilt University Medical Center; Lunds Universitet; Johns Hopkins University; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Emory University; Wellcome Trust; University College London; Imperial College London; Faculty of Medicine and Health, University of Sydney; Vanderbilt University; Science for Life Laboratory; Vetenskapsrådet; Australian Government","keywords":"Neurodegeneration; Amyotrophic lateral sclerosis; Disease; Proteomics; Biomarker; Biomarker discovery; Frontotemporal dementia; Proteome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001940616,0.0001401061,0.0001964867,0.00003562659,0.0004015811,0.0002720222,0.00007506921,0.00003669417,0.000002233536],"category_scores_gemma":[0.0002318913,0.000091089,0.0000436881,0.0001549016,0.0002397053,0.000191927,0.0001477682,0.0001039624,5.837296e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006545382,"about_ca_system_score_gemma":0.0001048099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005734522,"about_ca_topic_score_gemma":0.00005020152,"domain_scores_codex":[0.998919,0.0001247163,0.0002058435,0.0003203364,0.0001624727,0.0002676403],"domain_scores_gemma":[0.9993525,0.0001842057,0.00004927757,0.0002134376,0.00008976335,0.0001108583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002249162,0.0002617103,0.8418979,0.0004463446,0.0003064892,0.00002515914,0.0002029647,0.00007283582,0.08007014,0.02643033,0.01803799,0.02999896],"study_design_scores_gemma":[0.001912148,0.0001240001,0.9681359,0.00007463015,0.0001076368,0.00001125544,0.00005632271,0.01416565,0.00653764,0.003448883,0.005263474,0.0001624888],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706663,0.00167939,0.002066881,0.0237067,0.0001607194,0.001362141,0.0001308916,0.00003350592,0.0001934424],"genre_scores_gemma":[0.9965601,0.0003349557,0.0005428406,0.0008766235,0.00009442199,0.0002104915,0.00006156731,0.00001266057,0.001306366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1262379,"threshold_uncertainty_score":0.3714502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652446829218279,"score_gpt":0.3073578988152019,"score_spread":0.2908334305230191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}