{"id":"W7132492668","doi":"","title":"The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging","year":2025,"lang":"en","type":"article","venue":"DZNE Pub","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; National Institute of Neurological Disorders and Stroke; National Institute on Aging; School of Public Health, Imperial College London; Instituto de Salud Carlos III; National Center for Advancing Translational Sciences; Medical Research Council; Wu Tsai Neurosciences Institute, Stanford University; Parkinsonfonden; University of California, San Francisco; School of Medicine, Emory University; National Institutes of Health; Université de Montréal; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Skånes universitetssjukhus; Alzheimer Nederland; Knut och Alice Wallenbergs Stiftelse; Janssen Research and Development; Generalitat de Catalunya; School of Medicine, Indiana University; Helsingin Yliopisto; GHR Foundation; European Commission; Sun Health Foundation; Vanderbilt University Medical Center; Lunds Universitet; Johns Hopkins University; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Emory University; Wellcome Trust; University College London; Imperial College London; Faculty of Medicine and Health, University of Sydney; Vanderbilt University; Science for Life Laboratory; Vetenskapsrådet; Australian Government","keywords":"Neurodegeneration; Amyotrophic lateral sclerosis; Disease; Proteomics; Biomarker; Biomarker discovery; Frontotemporal dementia; Proteome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01118357,0.002761609,0.003261668,0.007153642,0.001727807,0.00550537,0.003053631,0.002516351,0.008401346],"category_scores_gemma":[0.009244806,0.0004707611,0.001576364,0.009894124,0.0007844816,0.00275181,0.008374959,0.002249263,0.008230082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002608558,"about_ca_system_score_gemma":0.01415356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006932559,"about_ca_topic_score_gemma":0.01287524,"domain_scores_codex":[0.9953871,0.001115985,0.0002880478,0.0009097697,0.001758408,0.0005406246],"domain_scores_gemma":[0.9910067,0.0006797306,0.001035416,0.001316183,0.003372581,0.002589288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.001071324,0.0003045959,0.01010555,0.002471948,0.0006313765,0.0004149869,0.0002138017,0.001381976,0.01410045,0.005504803,0.7745964,0.1892027],"study_design_scores_gemma":[0.0008649749,0.0007412782,0.02862515,0.001577571,0.000683622,0.0008782738,0.000347371,0.006072698,0.01153033,0.01367591,0.9348281,0.0001746735],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.05634221,0.1450574,0.04200561,0.06682792,0.005413001,0.005102744,0.5907656,0.01908392,0.0694016],"genre_scores_gemma":[0.07673595,0.04192675,0.08253577,0.01659659,0.002201767,0.003311579,0.75865,0.001473861,0.01656772],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01118357,"threshold_uncertainty_score":0.05914509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652446829218279,"score_gpt":0.3073578988152019,"score_spread":0.2908334305230191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}