{"id":"W7132860175","doi":"","title":"Biocompatible nanoemulsions as a tool for preclinical testing of CW-02-79, a pyrazoloquinolinone modulator of sigma-2 receptors: preformulation and formulation studies","year":2023,"lang":"en","type":"article","venue":"FarFar - Pharmacy Repository","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biocompatible material; In vivo; Receptor; In vitro; Drug discovery; Preclinical testing","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004662928,0.000406315,0.000204435,0.0002455548,0.0001031646,0.0001758542,0.0001751794,0.0002932876,0.0005167407],"category_scores_gemma":[0.0002136206,0.0000962631,0.000199901,0.0001433948,0.0002100282,0.0002056159,0.0001275181,0.0003946134,0.000199731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243741,"about_ca_system_score_gemma":0.0001699322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000431819,"about_ca_topic_score_gemma":0.0005358081,"domain_scores_codex":[0.9998862,0.00001442094,0.00001473252,0.00002445876,0.0000425881,0.00001761866],"domain_scores_gemma":[0.9998823,0.00002100076,0.00004541203,0.000009492273,0.00002763897,0.00001404302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003187233,0.00003432739,0.00003409532,0.0000582692,0.000002078089,0.00002204345,0.00001178179,0.00009400071,0.9984038,0.00004610546,0.00001691787,0.001244671],"study_design_scores_gemma":[0.0000102981,0.001079356,0.0003333504,0.000007752992,0.00001139051,0.00005566999,0.000008002808,0.0003573717,0.9967254,0.0000166006,0.001391013,0.000003632857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970857,0.004798796,0.02159765,0.00007846224,0.00006213685,0.0005350942,0.0005462194,0.0001256557,0.001398949],"genre_scores_gemma":[0.9707144,0.004172218,0.02211532,0.00006038491,0.00002346759,0.0003902648,0.0004756809,0.00003113402,0.002017159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005167407,"threshold_uncertainty_score":0.002465963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08510945275508523,"score_gpt":0.3928485805724067,"score_spread":0.3077391278173214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}