{"id":"W7132861660","doi":"","title":"Common Genetic Variants in CHRNA5 Alter β-amyloid Neuropathology and Highlight Chandelier Cells in Human Aging and Alzheimer’s Disease","year":2022,"lang":"","type":"dissertation","venue":"TSpace","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Neuropathology; Nicotinic acetylcholine receptor; Allele; Context (archaeology); Nicotinic agonist; Genotype; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365071,0.0003105483,0.000167648,0.0003963484,0.0002182202,0.0002849191,0.0001420381,0.0003398795,0.00407188],"category_scores_gemma":[0.000257403,0.00007877235,0.0002050153,0.0003222002,0.0001302085,0.0001080187,0.0001679612,0.0001758552,0.0003309361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341088,"about_ca_system_score_gemma":0.0001167885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002538086,"about_ca_topic_score_gemma":0.003393242,"domain_scores_codex":[0.9999324,0.000009215404,0.000006302294,0.0000280291,0.00001198694,0.00001200113],"domain_scores_gemma":[0.9999373,0.00001154288,0.00001647171,0.000008280576,0.00001042101,0.00001606607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005317256,0.0003565221,0.364925,0.0003188486,0.0005252968,0.004290734,0.001412735,0.0002248203,0.5590983,0.0008401607,0.001003217,0.06168712],"study_design_scores_gemma":[0.00002907496,0.0003079584,0.9856198,0.0000229718,0.0001445715,0.00183289,0.0002324909,0.0001095058,0.009660861,0.0003295324,0.001703465,0.000006966009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964265,0.001397631,0.0004776,0.0000734713,0.00001683085,0.00001023585,0.0002727422,0.0000110824,0.001313905],"genre_scores_gemma":[0.9965271,0.0005761428,0.0002843496,0.00003926781,0.0000136542,0.000005461504,0.0002428991,0.000004921627,0.002306128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00407188,"threshold_uncertainty_score":0.01362181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01287273091790864,"score_gpt":0.3144921414669682,"score_spread":0.3016194105490596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}