{"id":"W7132863825","doi":"","title":"Targeting the MYC Oncoprotein by Disrupting the MYC-PNUTS Interaction","year":2023,"lang":"","type":"dissertation","venue":"TSpace","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Protein subunit; Protein–protein interaction; Hyperphosphorylation; Phosphorylation; Phosphatase; Signal transducing adaptor protein; Mutation; Plasma protein binding; Protein phosphatase 1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373163,0.000329813,0.0001759723,0.0001170053,0.0001566007,0.0002901548,0.0002499486,0.0002700489,0.0008022873],"category_scores_gemma":[0.00008867047,0.0001513998,0.0002278927,0.0001051266,0.0003045053,0.0001629701,0.0002725706,0.0005396728,0.000259243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603818,"about_ca_system_score_gemma":0.0002412719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004031757,"about_ca_topic_score_gemma":0.0005423282,"domain_scores_codex":[0.9998925,0.00001305774,0.000009046631,0.00002429564,0.00004003791,0.00002107561],"domain_scores_gemma":[0.9999231,0.00001678207,0.00003465862,0.000005510227,0.000003465448,0.00001640596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004390144,0.00001703986,0.00006506697,0.00001767067,0.000002057473,0.00003703775,0.000004643947,0.0001080131,0.9990138,0.0002760631,0.00001232124,0.0004023346],"study_design_scores_gemma":[0.000007262607,0.0001392487,0.000494357,0.000001522235,0.00000435213,0.0001298601,0.000006081297,0.0008504447,0.9969563,0.00002956932,0.001378645,0.000002278006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843416,0.0005592592,0.01269649,0.0001068571,0.00003060832,0.00008780442,0.0002021583,0.0001197177,0.001855498],"genre_scores_gemma":[0.9920684,0.0004581803,0.005422585,0.00003185796,0.00000618428,0.00004126833,0.0001848501,0.0000193106,0.001767372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008022873,"threshold_uncertainty_score":0.002683878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400329354241508,"score_gpt":0.3322798201334506,"score_spread":0.3182765265910355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}