{"id":"W7132877778","doi":"","title":"Structural Studies of Histone H3K36 Methyltransferase NSD1 and CRL2 Substrate Receptors FEM1B/C","year":2023,"lang":"","type":"dissertation","venue":"TSpace","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Methyltransferase; Transferase; Histone; Arginine; Ubiquitin ligase; Nucleosome; Methylation; Substrate (aquarium); Histone methyltransferase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589319,0.000297003,0.0003128976,0.0001269276,0.0004452167,0.0003240408,0.0007530847,0.0004046186,0.001763864],"category_scores_gemma":[0.0002051068,0.0001823345,0.000383014,0.0002444387,0.0001387458,0.0003098921,0.0002595655,0.0006989351,0.000403447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001594118,"about_ca_system_score_gemma":0.0005926721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01234702,"about_ca_topic_score_gemma":0.007732032,"domain_scores_codex":[0.999876,0.00001383067,0.000005502129,0.00002623705,0.00004913872,0.00002930686],"domain_scores_gemma":[0.9999257,0.00001091695,0.00001527902,0.000004346951,0.00001531764,0.00002841646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001432893,0.000440619,0.009470955,0.0008635982,0.0001923705,0.001509055,0.0006352379,0.01729375,0.9417654,0.005439723,0.006937903,0.01401846],"study_design_scores_gemma":[0.0003156546,0.0005472304,0.03690796,0.0001408822,0.0001698205,0.001675341,0.0009110027,0.1036626,0.8096104,0.0008719974,0.04509687,0.00009014085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904557,0.003483847,0.001165301,0.0005211706,0.00004286434,0.00001448475,0.0007250236,0.0000528448,0.003538742],"genre_scores_gemma":[0.9863703,0.002580187,0.003183802,0.0001326438,0.0000109534,0.00001726786,0.002788876,0.00002705437,0.004888939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01234702,"threshold_uncertainty_score":0.02455032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03004762949894286,"score_gpt":0.391670574567582,"score_spread":0.3616229450686392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}