{"id":"W7132877778","doi":"","title":"Structural Studies of Histone H3K36 Methyltransferase NSD1 and CRL2 Substrate Receptors FEM1B/C","year":2023,"lang":"","type":"dissertation","venue":"TSpace","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Methyltransferase; Transferase; Histone; Arginine; Ubiquitin ligase; Nucleosome; Methylation; Substrate (aquarium); Histone methyltransferase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003351451,0.000708762,0.0009057027,0.0002304795,0.0002331599,0.00003110413,0.0002210196,0.0009365698,0.00009298663],"category_scores_gemma":[0.0001955498,0.0007634866,0.0002912351,0.0004470147,0.0004466625,0.00001014837,0.00007071274,0.0003684399,0.000009962052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404897,"about_ca_system_score_gemma":0.0003377529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005013727,"about_ca_topic_score_gemma":0.001787359,"domain_scores_codex":[0.997054,0.0002045692,0.0008282582,0.001041488,0.0003861912,0.000485487],"domain_scores_gemma":[0.9980302,0.0000801509,0.0005723823,0.0005693068,0.0005788647,0.000169042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001195137,0.00003153312,0.0003387389,0.001329484,0.001583645,0.000005454494,0.0132576,0.001092186,0.9683911,0.00003916658,0.00117244,0.01156352],"study_design_scores_gemma":[0.001571071,0.0008276993,0.008856799,0.0004565098,0.0008763776,0.00001402101,0.0217951,0.0002001289,0.9628393,0.0001373815,0.001416306,0.001009297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458292,0.05034792,0.00002401046,0.0002259087,0.002664143,0.0006441035,0.00005484015,0.00003188741,0.0001779458],"genre_scores_gemma":[0.9538344,0.02505137,0.0001895323,0.0000132213,0.0003427776,0.00004607624,0.002060602,0.0001319761,0.01833001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02529655,"threshold_uncertainty_score":0.9994816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03004762949894286,"score_gpt":0.391670574567582,"score_spread":0.3616229450686392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}